Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 2008; 319: 1676–1679. Article CAS Google Scholar Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q et al. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large...
revealed the importance of this site in TNF[alpha] and IL-1[beta]-mediated IKK/NF-[kappa]B and JNK/AP-1 activation as well as IL-6 gene ... Y Fan,Y Yang,S Yi,... - 《Journal of Biological Chemistry》 被引量: 125发表: 2010年 Abstract 23: Disruption of TRAF2-TAK1-NF-κB Si...
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 2008; 319: 1676–1679. 7 Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q et al. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. Cancer...
ArticleCASPubMedGoogle Scholar Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M . (1999). Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.Genes Dev13: 1297...
Transforming growth factor β activated kinase-1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase family, has emerged as a key regulator of signal transduction cascades leading to the activation of the transcription factors nuclear
Therefore, we hypothesized that TRAF6 might also be involved in C-type lectin receptor-induced NF-κB activation downstream of the CARD9-Bcl10-MALT1 complex. It has been shown that TRAF6 interacts with TAK1 through the TAK1-associating protein TAB2 in response to various stimuli including TLR...
revealed the importance of this site in TNF[alpha] and IL-1[beta]-mediated IKK/NF-[kappa]B and JNK/AP-1 activation as well as IL-6 gene ... Y Fan,Y Yang,S Yi,... - 《Journal of Biological Chemistry》 被引量: 125发表: 2010年 ...
Vidal, S. et al. Mutations in theDrosophiladTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses.Genes Dev.15 ArticleCASGoogle Scholar Takaesu, G. et al. TAK1 is critical for IκB kinase-mediated activation of the NF-κB pathwa...
Myocardial hypertrophy, an inflammatory condition of cardiac muscles is a maladaptive response of the heart to biomechanical stress, hemodynamic or neurohormonal stimuli. Previous studies indicated that knockout of Arginyltransferase (ATE1) gene in mice and embryos leads to contractile dysfunction, defecti...
A.C. is an advisor for Merck Serono, Roche, Beigene, Bayer, Servier, Lilly, Novartis, Takeda, Astelas, Pierre Fabre, Amgen and Foundation Medicine. He has received grants from Merck Serono and Roche, and research funding from Genentech, Merck Serono, Roche, Beigene, Bayer, Servier, Lilly...