Indusatumab Vedotin(MLN-0264; AKT-264) 是一种 靶向 GCC(鸟苷酸环化酶 C) 的抗体-药物偶联物(ADC),由 人源化抗 GCC 单克隆抗体 通过 可裂解的连接子 偶联 微管破坏剂 MMAE(Monomethyl Auristatin E) 组成。 Indusatumab Vedotin 作用机制 靶向结合:Indusatumab Vedotin 通过抗体部分特异性结合 GCC,选择性靶...
Methods Patients with advanced or metastatic pancreatic adenocarcinoma expressing GCC (H-score ≥ 10) received TAK-264 1.8 mg/kg on day 1 of a 21-day cycle as a 30-min intravenous infusion for up to 1 year or until disease progression or unacceptable toxicity. The primary objective...