CAR-T cellsTAG-72ovarian cancerCRISPR-Cas9DGKEvtimov and colleagues demonstrate that CRISPR-engineered deletion of two key immune-suppressor genes in TAG-72 targeting CAR-T cells greatly improves their ability t
Furthermore, we could reduce the damage to normal tissue by monomerizing the CD47 CAR. Our results indicate that the co-expression of the TAG-72 CAR and the CD47-truncated monomer CAR on T cells could be an effective, dual CAR-T cell strategy for ovarian cancer, also applicable to other...
In various embodiments, an agent targeting TAG-72 comprises a cell expressing a CAR specific for TAG-72. In some embodiments, the cell is a T cell, such as a γδ TCR T cell, a αβTCR T cell, an NKT cell, or a MAIT (Mucosal associated invariant T) cell; and in other embodiment...
cyclophosphamide, cis-platinum, vindesine, vinca alkaloids, mitomycin, bleomycin, purothionin, macromomycin, 1,4-benzoquinone derivatives, trenimon, steroids, aminopterin, anthracyclines, demecolcine, mithramycin, daunomycin, vinblastine, neocarzinostatin, macromycin, a-amanitin, and combinations thereof...
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Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy 2011, Expert Opinion on Biological Therapy Targeting of G<inf>D2</inf>-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes 2001, International Journal of Cancer Chimeric Fv-ζ or ...