Tafenoquine cost-effective option in Plasmodium vivax malariadoi:10.1007/s40274-019-6274-yTafenoquine is a cost-effective option for radical cure of Plasmodium vivax (PV) malaria, compared with primaquine, in Serbia, report researchers from that country.PharmacoEconomics & Outcomes News...
Bioavailability/bioequivalence studies supporting clinical drug development or commercial supply of drug formulations are often time, cost, and resource intensive. The drug’s pharmacokinetic (PK) variability, systemic half-life, and safety issues may pose additional challenges. The stable isotope label (...
摘要: Bioavailability/bioequivalence studies supporting clinical drug development or commercial supply of drug formulations are often time, cost, and resource intensive. The drug's pharmacokinetic (PK)...关键词: bioavailability dissolution profiles pharmacokinetics stable isotope label tafenoquine ...
cost-effectivenessMarkov modelPlasmodium vivax malariaThe aim of this study was to compare cost-utility of tafenoquine (TQ) and primaquine (PQ) for a radical cure (prevention of relapse) of Plasmodium vivax (PV) malaria in Serbia using A five-state, 1-month cycle Markov model. The perspective...
Global implementation of tafenoquine will require the development and validation of a robust, low-cost diagnostic to reliably identify G6PD-deficient individuals. In addition, studies on tafenoquine safety in children are needed.doi:10.1097/QCO.0000000000000574Chen, Victor...
While the impact of changing policies to tafenoquine after G6PD screening on transmission has been evaluated, the associated costs and cost-effectiveness will be important considerations for policymakers. What did the researchers find?: Using an economic evaluation model coupled wi...
There are some methods for the quantification of tafenoquine in plasma, but none uses dispersive﹍iquid﹍iquid microextraction, an extraction technique that shows some advantages, such as miniaturization, low cost and high potential for routine application. Therefore, this study evaluated the employment...
of tafenoquine addresses key requirements for a mass administration, eradication campaign: excellent subcutaneous bioavailability, complete parasite control after a single dose, improved therapeutic window compared to the parent oral drug, and low cost of goods sold (COGS) at less than $1.50 per dose...