In case of liver transplant, the adult therapeutic level required for tacrolimus is 6–9 ng/mL (< 1 month), 4–8 ng/mL (1–3 months), 4–6 ng/mL (> 3 months) and 3–5 ng/mL (> 12 months). In case of heart transplant, the monitored dose is 9–12 ng/mL (< 3 months),...
Tacrolimus in heart transplant recipients: an overview. Biodrugs 2007;21:139-43.Patel JK, Kobashigawa JA. Tacrolimus in heart transplant recipients: an overview. BioDrugs 2007;21(3):139-43.Patel JK,Kobashigawa JA.Tacrolimus in heart transplant recipients: an overview. BioDrugs Clinical ...
Heart TransplantationImmunosuppressive AgentsTacrolimus移植物排斥心脏移植免疫抑制剂他罗利姆Calcineurin inhibitors have been at the core of immunosuppression for heart transplant recipients. Traditional ciclosporin and later modified microemulsion ciclosporin enabled prolonged cardiac allograft survival and in ...
The article presents the author's comments on the effectiveness of drug tacrolimus in heart transplant recipients. It acts as a potent calcineurin inhibitor that offers significant immunosuppression when administered with azathioprine. There is not much difference in overall incidence of significant ...
For Heart Transplant With azathioprine or Mycophenolate mofetil(MMF): 0.075 mg/kg/day, divided in two doses, administered every 12 hours Month 1-3: 10-20 ng/mL Month ≥ 4: 5-15 ng/mLPEDIATRIC PATIENTS: Liver Transplant: 0.15-0.2 mg/kg/day capsules divided in two doses, every 12 ...
Tacrolimusis used with othermedicationsto prevent rejection of akidney,heart,liver, orlung transplant. Thismedicationbelongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were yo...
Heart Transplant With azathioprine or MMF 0.075 mg/kg/day, divided in two doses, administered every 12 hours Month 1 to 3: 10 to 20 ng/mL Month ≥ 4: 5 to 15 ng/mL Dosing should be titrated based on clinical assessments of rejection and tolerability. Lower tacrolimus capsules dos...
PROGRAF is an anti-rejection medication for kidney, liver, or heart transplant patients. Please see complete Prescribing Information, including boxed warning.
No significant differences were detected in the total daily dose administered either by tacrolimus level-to-dose ratio before or after conversion. Kidney transplant recipients under Tac-O therapy were safely maintained using the same therapeutic monitoring as when receiving Tac-T. 展开 关键词: Oral...
Heart Transplant:In combination with an antimetabolite Oral: IR: Initially 0.075 mg/kg/day in two divided doses, given every 12 hours IV: Initially 0.01 mg/kg/day as a continuous infusion Kidney Transplant:Use in combination with an antimetabolite agent ...