Methods This study is a retrospective cohort single center chart review performed with 348 consecutive adult patients who received an aHSCT and were followed for at least 100 days post-transplant for aGvHD development. Patients that received a transplant from a cord blood or participated in aGvHD ...
It has also been found that very low dose of tacrolimus or its close structural analogue has a beneficial effect on blood fat levels and particularly on the blood levels of cholesterol and of triglycerides. Accordingly, the present invention provides a method of treating high blood fat levels whi...
Tacrolimus has a very narrow range of therapeutic blood levels because it increases the risk of infection if taken more than necessary and can result in transplant rejection if taken less than necessary [7]. Thus, the TTL would have been finely adjusted to maintain the therapeutic blood levels....
Like cyclosporin, the pharmacokinetic properties of tacrolimus can vary widely between individuals and dosage regimens are titrated according to whole-blood trough drug concentrations. Oral bioavailability of tacrolimus is about 20 to 25%, and food appears to have a significant effect in reducing the r...
Patients receiving tacrolimus experienced lower serum creatinine levels at months 3 through 36 (p < 0.0001). Systolic blood pressure was lower in patients receiving tacrolimus (p < 0.001) despite a reduced requirement for anti-hypertensive agents (p < 0.0001). In addition, tacrolimus was associated...
Most of the published data used whole blood trough levels for drug monitoring. However, the use of limited sampling strategy and abbreviated formula to estimate the 12-h area under concentration-time curve (AUC(0-12)) allowed better prediction of drug exposure. Sixty-six first cadaveric renal ...
Retrospective analyses indicated that whereas mean MPA plasma levels >3.0 μg/mL were not associated with rejection, no correlation was found with tacrolimus blood concentrations. Phase II: A survival rate of 96.7% was evident, one patient having died from aspergillosis. Diagnoses of rejection were...
In several small studies in adult heart transplant recipients, tacrolimus-based rescue therapy was effective in the vast majority of patients at up to 3 years of follow-up, with patients showing marked improvements in systolic and diastolic blood pressure, total serum cholesterol levels and triglyceri...
Dried blood spotting (DBS) may act as a suitable alternative for tacrolimus TDM due to relative ease of sampling and processing. The objective of this literature review was to provide a critical evaluation on the feasibility (i.e., accuracy and precision) of DBS for predicting tacrolimus whole...