Drug mechanism, systemic and ocular complications and toxicity, drug interactions and contraindications are summarized inTable 36.1.2,6–8 Summary and key points CsA andtacrolimusare effective second-line agents. However, despite the use of low-dose regimens, CsA toxicity (renal toxicity, hypertension...
Author Information Drug interaction A 16-year-old girl developed an increased tacrolimus concentration and renal toxicity due to a pharmacokinetic interaction between tacrolimus and berberine. The girl started receiving immunosuppressive therapy which included tacrolimus 0.1mg/kg twice daily [ route not ...
Tacrolimus toxicity commonly presents as acute renal failure. Close monitoring of serum creatinine, GFR, and urine output is necessary for patients on tacrolimus. Toxicity may also present as the development of adverse effects such as tremors, electrolyte disturbances, headaches, and increased SCr. No...
toxicity as well as an increase in incidence of abortions. At the higher dose only, an increased incidence of malformations and developmental variations was also seen. Tacrolimus, at oral doses of 3.2 mg/kg during organogenesis in rats, was associated with maternal toxicity and caused an ...
Tacrolimus at oral doses of 0.32 and 1.0 mg/kg (0.04X-0.12X MRHD based on BSA) during organogenesis in rabbits was associated with maternal toxicity as well as an increase in incidence of abortions. At the higher dose only, an increased incidence of malformations and developmental variations ...
Mild renal toxicity was common before day 100; 63% of patients had a doubling of creatinine, and 52% had a peak creatinine greater than 2 mg/dL, but only one patient was dialyzed. The median last IV dose of tacrolimus was 53% of the scheduled dose, and the median oral dose on day ...
Blood concentration monitoring is not a replacement for renal and liver function monitoring and tissue biopsies. Data from clinical trials show that tacrolimus whole blood concentrations were most variable during the first week post-transplantation. The relative risks of toxicity and efficacy failure ...
191-2. adverse effects, tr eatment, and precautions the most common adverse effects after systemic use of tacrolimus include tremor, headache, paraesthesias, nausea and diarrhoea, hypertension, insomnia, and renal impair ment. disturbances of serum electrolytes, notably hyper kalaemia, and ...
Graft function, biopsy-proven rejection, cytomegalovirus (CMV) and BK virus viremia, and calcineurin inhibitor (CNI) toxicity were evaluated. Results. Of 202 transplant recipients, 128 were included with a mean age of 45.48 +/- 13.14 years. The median Tac-IPV was 13.28% with 43.75% of ...
Background: Tacrolimus (Tac) is an immunosuppressive drug used to prevent post-transplant (PT) organ rejection. Continuous Tac monitoring is necessary to adjust the dose and prevent toxicity or rejection. Tac is metabolized by cytochrome-P450 (CYP) enzym