loss after 28 days demonstrated that up to 57% of VK2735-treated subjects achieved ≥5% weight loss, compared with 0% for placebo. Based on a preliminary evaluation of weight loss trajectory, the company believes that treatment...
The TGA investigations highlighted the stability of the API at the employed working temperatures, which was further confirmed by the present evaluation. The relatively lower API-loading values in both filaments and tablets compared to the theoretical ones were presumably obtained due to the fine DCNa...
2.6. Evaluation of Change in Tabletability 2.6.1. The Reworking Potential The reworking potential (RP) index was first proposed by Malkowska et al. [8]. In this method, the tabletability change of the material was calculated by dividing the area under the tensile strength vs. compression pre...
The best LS values for each individual binder that could form acceptable 14 × 14 mm squares with mannitol at different bulk:binder ratios were selected to print tablets for evaluation. The results are categorized as mentioned previously inSection 2.4and presented inTable 3. HPC-LFP presented the...
Since the global prevalence of dementia (5–7% of world population in 2010) is expected to increase due to the aging of the population, the clinical needs for suitable dosage forms will increase as well [14,15]. In Italy, neurologists from the Alzheimer Evaluation Centers can prescribe atypic...
Table 7. Evaluation parameters of granules. The bulk density of granules was found to be between 0.461 g/mL and 0.755 g/mL. The values indicate good packing characteristics [25]. The tapped density of granules of three batches was found in the range of 0.499 g/mL to 0.834 g/mL. The...