EGFR T790M mutation: a double role in lung cancer cell survival? J Thorac Oncol. 2009; 4 (1):1–4. doi: 10.1097/JTO.0b013e3181913c9f. [ Cross Ref ]Suda, K., Onozato, R., Yatabe, Y., & Mitsudomi, T. (2009). EGFR T790M mutation: a double role in lung cancer cell survival...
参考文献: E-E Ke, PhD, et al., A Higher Proportion of the EGFR T790M Mutation May Contribute to the Better Survival of Patients with Exon 19 Deletions Compared with Those with L858R,Journal of Thoracic Oncology Vol. 12 No. 9: 1...
E-E Ke, PhD, et al., A Higher Proportion of the EGFR T790M Mutation May Contribute to the Better Survival of Patients with Exon 19 Deletions Compared with Those with L858R,Journal of Thoracic Oncology Vol. 12 No. 9: 1368-1375
EGFRT790M突变是最普遍的EGFRTKIs获得性耐药机制之一,约占所有耐药病例的50-60%,可从第三代TKIs如奥希替尼中获益。因此,准确检测获得性EGFRT790M突变至关重要。 近日发表的一项研究“Clinical utility of repeated rebiopsy forEGFRT790M ...
参考文献: E-E Ke, PhD, et al., A Higher Proportion of the EGFR T790M Mutation May Contribute to the Better Survival of Patients with Exon 19 Deletions Compared with Those with L858R,Journal of Thoracic Oncology Vol. 12 No. 9: 1368-1375...
参考文献:Sagan OA, Rothstein A, Jambunathan B, Hadziahmetovic M, Antoniolli A and Rashid MH (2023) Case report: Neuroendocrine breast carcinoma with a germline EGFR T790M mutation. Front. Oncol. 13:1176868. doi: 10.3389/fonc.2023.1176868
参考文献:Sagan OA, Rothstein A, Jambunathan B, Hadziahmetovic M, Antoniolli A and Rashid MH (2023) Case report: Neuroendocrine breast carcinoma with a germline EGFR T790M mutation. Front. Oncol. 13:1176868. doi: 10.3389/fonc.2023.1176868
Yazaki T, Kimoto M, Minagawa A, Maruno T, Yamanaka M, Sonehara K, Hama M, Nakamura T, Kanda S, Hanaoka M, Hachiya T. Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report. Am J Case Rep. 2024 ...
参考文献: Sagan OA, Rothstein A, Jambunathan B, Hadziahmetovic M, Antoniolli A and Rashid MH (2023) Case report: Neuroendocrine breast carcinoma with a germline EGFR T790M mutation. Front. Oncol. 13:1176868. doi: 10.3389/fonc.2023.1176868...
并且该研究还发现药理性抑制NFĸB通路或者去除AICDA能够减少或阻止T790M突变。 最后,整理出T790M发生的机制,如下图: The EGFR T790M mutation is acquired through AICDA-mediated deamination of 5-methylcytosine following TKI treatment in lung cancer.