结论体外和体内实验均提示,ERH基因敲除影响人膀胱癌T24和5637细胞的迁移与侵袭。 关键词: 转录因子;细胞周期蛋白质类;膀胱肿瘤;细胞迁移分析;体外研究 ABSTRACT ObjectiveTo study the effect of enhancer of rudimentary homolog (ERH) gene on migration and invasion in human bladder cancer T24 and 5637 cells. ...
Conclusions: The results obtained from both experiments suggest that LBP can inhibit the proliferation of T24 and 5637 BC cells, which might be credited to its effects in regulating Bcl-2 and Bax expression and inhibiting the PI3K/Akt pathway.Qian Yu...
In order to prove the utility of this platform, we chose β-catenin and HIF-1α as the functional targets and used the bladder cancer cell lines 5637 and T24 as the test models. We found that the Tet-inducible artificial microRNAs can effectively silence the target genes and their ...
Sirolimus inhibits the growth of bladder carcinoma cells and decreases their viability. Significant correlations were found between cell proliferation and sirolimus concentration (r = 0.830; p < 0.01) as well as between cell viability and sirolimus concentration (r = -0.896; p < 0.01). Conclusion...
Methods T24 bladder cells line were treated by 0.625, 1.25, 2.5,5,10 and 20 μmol/L sunibinib in 24, 48 and 72 h. The cytotoxic activity was analyzed by MTT. Results Sunitinib inhibited T24 cell proliferation in dose-dependent manner. When the plasma drug concentration exceeded up to 5...
Effect of CTP-mediated PTEN on 5637 bladder cancer cells and the underlying molecular mechanism Article Open access 10 December 2022 Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis Article 29 March 2018 PIK3CA dependence and sensitivity to therapeutic target...
cells,toblockthe proliferationdrug resistance signal transduction passageways andSOon. Key words:Proteinkinase C(PKC);Cancer;Signal trausduction 0 引言 自1977年蛋白激酶C(Protein kinase C,PKC)被人类发现以来,经过30年的研究, 发现PKC不仅广泛参与细胞信号转导、蛋白质磷酸化、细胞对生长因子应答等多种生 理...
73.72%.Allinhibitionswereinatime—and—dosedependentmanners.AfterPKC412acting48hours.with theincreasingofconcentration,G,/Mperiodcellsfrom12.26% increasedto58.4l% ,showedtheG,/M periodcellblock.Conclusion:PKC412decreasedcellgrowth,invasionandinhibitedcloningformationof ...
(▿) and primary bladder epithelial cells (□). PanelB: 5637 (▿), BFTC905 (□), HT1197 (○), and J82 (▵) were cell lines that were moderately inhibited. PanelC: relative sensitive cell lines include SCaBER (▵), TCCSUP (▿), and TSGH-8301 (□). These experiments were...
Berberine can significantly inhibit the migration, invasion, and cell cycle progression of T24 and 5637 bladder cancer cells, promote their apoptosis, and down-regulate the expression of HER2/PI3K/AKT proteins. Berberine showed good docking with HER2 molecular...