🔸T2/FLAIR不匹配是指肿瘤在T2加权成像(T2)上非常亮,但在FLAIR成像(FLAIR)上信号被饱和(消失)。 🔸 不匹配通常位于肿瘤的中央,周围有一圈小的FLAIR高信号残留。 🔸 这是星形胶质瘤(astrocytoma)(IDH突变型,1p19q非共缺失)的非常特异性的表现,...
T2-FLAIR mismatchBACKGROUND. The T2-FLAIR mismatch sign is an imaging correlate for isocitrate dehydrogenase (IDH)-mutant 1p19q non-codeleted astrocytomas. However, it is only seen in a part of the cases at certain stages. Many of the tumors likely lose T2 homogeneity as they grow in ...
肿瘤显示T2-FLAIR错配征,尽管存在个小结节增强,但术后病理证实为IDH突变的胶质母细胞瘤。 图5:27岁男性,左侧岛也弥漫星形细胞瘤,IDH突变,显示T2-FLAIR错配征。(A)最初1.5T MRI的T2WI和(B)FLAIR图像显示了左岛叶占位,T2WI上的高强度信号接近均匀,FLAIR上的低信号,但周围边缘薄层高信号。(C)一个月后进行的3T...
肿瘤显示T2-FLAIR错配征,尽管存在个小结节增强,但术后病理证实为IDH突变的胶质母细胞瘤。 图5:27岁男性,左侧岛也弥漫星形细胞瘤,IDH突变,显示T2-FLAIR错配征。(A)最初1.5T MRI的T2WI和(B)FLAIR图像显示了左岛叶占位,T2WI上的高强度信号接近均匀,FLAIR上的低信号,但周围边缘薄层高信号。(C)一个月后进行的3T...
BACKGROUND AND PURPOSE: T2-FLAIR mismatch is a highly specific imaging biomarker of IDH-mutant diffuse astrocytoma in adults. It has however also been described in MYB/MYBL1–altered low grade tumors. Our aim was to assess the diagnostic power of the T2-FLAIR mismatch in IDH-mutant ...
However, many IDH-mutant astrocytoma has the potential to progress to grade 4 glioblastomas, leading to a less favorable prognosis. In a recent investigation, Shumpei Onishi et al. examined the T2-FLAIR mismatch sign as a possible imaging biomarker for assessing CDKN2A status in non-enhancing ...
T2-FLAIR mismatch sign as a marker of IDH-mutant astrocytomas showed positive predictive value of 83%. Among 22 patients with IDH-mutant astrocytomas, microcystic change was found in eight, of which seven showed T2-FLAIR mismatch sign. Microcystic change was significantly associated with T2-FLAIR...
We present a case of the T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase (IDH)-wild type. The T2-FLAIR mismatch sign is known as a highly specific imaging finding of astrocytoma, IDH-mutant. Meanwhile, IDH-wildtype diffuse astrocytic gliomas with telomerase reverse transcriptase (...
In IDH-mutant gliomas, the T2-FLAIR mismatch sign is a characteristic imaging marker suggestive of astrocytoma. Recently, it has been reported that IDH-mutant astrocytoma showing this feature have a good prognosis; however, the reason for this is still unclear. In this study, we investigated ...
The sensitivity and specificity of the mismatch sign for IDH-mut astrocytoma detection were 20% and 98.6%, respectively. There were no differences between patients with an IDH-mut astrocytoma with or without T2FLAIR mismatch sign when grouped according to this with related t...