肿瘤显示T2-FLAIR错配征,尽管存在个小结节增强,但术后病理证实为IDH突变的胶质母细胞瘤。 图5:27岁男性,左侧岛也弥漫星形细胞瘤,IDH突变,显示T2-FLAIR错配征。(A)最初1.5T MRI的T2WI和(B)FLAIR图像显示了左岛叶占位,T2WI上的高强度信号接近均匀,FLAIR上的低信号,但周围边缘薄层高信号。(C)一个月后进行的3T...
T2-FLAIR mismatch was positive in 5 1p19q non-codeleted astrocytomas, 5 1p19q unknown ATRX mutant astrocytomas, and no 1p19q co-deleted oligodendrogliomas. Test sensitivity and specificity was 14% and 100% for 1p19q non-codeletion, 13% and 100% for ATRX mutation. CONCLUSION. Although ...
对于第二个标准,尽管FLAIR信号抑制的程度在肿瘤内可能不均匀,但相对于T2加权图像,绝大多数肿瘤应在FLAIR上显示低信号。重要的是,不应将T2-加权图像上高信号的瘤内区域和FLAIR上相应的低信号(如瘤内囊肿或坏死核心)与T2-FLAIR不匹配体征的标准相混淆(图3)。 图3:28岁女性,证实为少突胶质细胞瘤,无T2-FLAIR错配...
This imaging biomarker may enable preoperative prediction of CDKN2A status among astrocytoma, IDH-mutant. 展开 关键词: T2-FLAIR mismatch sign Glioma Astrocytoma IDH-mutant CDKN2A homozygous deletion DOI: 10.1007/s10143-024-02632-5 年份: 2024
T 2-FLAIR mismatch refers to a lesion with complete/near-complete homogenous hyperintense signal on T 2WI,and relatively hypointense signal on T 2-FLAIR.It has a high specificity for the diagnosis of IDH -mutant 1p/19q non-codeleted astrocytoma,and can be used to preoperatively predict the...
T2/T2-FLAIR mismatch sign as a predictive biomarker for anaplastic astrocytoma genetic profile The aim of the study was to assess T2/T2-FLAIR mismatch phenomenon as a predictor of particular genetic profile in the anaplastic astrocytoma group, includ... AY Belyaev,DY Usachev,IN Pronin,... - ...
T2-FLAIR mismatch signNon-enhancing gliomaImaging biomarkerDiffuse gliomaThe T2-FLAIR mismatch sign is a highly specific diagnostic imaging biomarker for astrocytoma, IDH-mutant. However, a definitive prognostic imaging biomarker has yet to be identified. This study investigated imaging prognostic markers,...
T2-FLAIR mismatchBACKGROUND. The T2-FLAIR mismatch sign is an imaging correlate for isocitrate dehydrogenase (IDH)-mutant 1p19q non-codeleted astrocytomas. However, it is only seen in a part of the cases at certain stages. Many of the tumors likely lose T2 homogeneity as they grow in ...
However, many IDH-mutant astrocytoma has the potential to progress to grade 4 glioblastomas, leading to a less favorable prognosis. In a recent investigation, Shumpei Onishi et al. examined the T2-FLAIR mismatch sign as a possible imaging biomarker for assessing CDKN2A status in non-enhancing ...
“T2-FLAIR错配”征是近年来影像基因组学领域中发现的最具突破的特征,是常规MRI可检测到的独特影像学特征,能够辅助在术前诊断IDH突变型星形细胞瘤(有IDH突变,但没有1p / 19q共缺失),并且具有一定的特异性。来自纽约大学Langone医学中心的Jain等回顾了“T2-FLAIR错配”征在真实世界的临床研究情况,并提供了识别T2...