2.2T-tubule function T-tubulesare a specialized membrane domain that facilitates transmembraneion flux, providing an electric pathway from the surface of the cardiac myocyte to the cell interior. For many years,
In heart muscle cells, a region of the sarcolemmal membrane periodically invaginates to form T tubules, a specialized membrane domain that contains important ion channels regulating cell contraction. Robin Shaw and his colleagues describe how a cardiac-s
T-tubule BIN1 Cardiomyocyte Excitation–contraction coupling Microdomains Heart failure 1. Introduction Each beat-to-beat heart contraction is a result of the synchronous contraction of millions of cardiac muscle cells initiated by a single action potential. To generate a coordinated and effective contract...
The meaning of T TUBULE is any of the small tubules which run transversely through a striated muscle fiber and through which electrical impulses are transmitted from the sarcoplasm to the fiber's interior.
A T-tubule is a transverse invagination of the sarcolemma, which occurs at characteristic sites in animal species and organs, i.e. at the Z-membrane in cardiac ventricle muscle and non-mammalian vertebrate skeletal muscle and at the A-I junction in mammalian skeletal muscle. It is absent in...
(Mg29), an important t-tubule organizing protein in skeletal muscle, was induced in the mouse heart for the first time during dilated cardiomyopathy with heart failure. Here we generated cardiac-specific transgenic mice expressing Mg29 to model this observed induction in the failing heart. ...
T tubule 横管,横小管 相关短语 Walther's duct (舌下腺小管) 瓦尔特氏管 traverse (横向) 往复移动 travelling roller table (横行的) 输送辊道 serrated end (管的) 收缩端 knee bend (弯管) 直角弯头 transfer arrangement(横移轧件用的) 拖运装置 short transverse (横截面中的短边) 高度方向 compressive ...
英文: DYNAMICS AND REGULATION OF MICRO TUBULE SYSTEM中文: 微管骨架的动态特性及其调控 英文: Immune modulation mechanism of renal tubule assist device中文: 辅助肾小管装置免疫调节机理研究 英文: CONSTRUCTION OF RECOMBINANT hNaDC3/GFP AND ITS LOCALIZATION IN RENAL PROXIMAL TUBULE EPITHELIA中文: 绿色荧光...
using an adenoviral vector (Poulet et al., 2021). Transfection of cultured cells with Bin-1 has previously been shown to cause t-tubule biogenesis, although it is not known whether overexpression of Bin-1 would rescue t-tubules in adult cardiac myocytes in culture (De ...
Dysregulation of BIN1 splicing, e.g., during myocardial infarction, underlied T-tubule disorganization, and correction of uBIN1/pBIN1 stoichiometry rescued T-tubule morphology in heart disease. 中文翻译: 纳米棒阵列分析揭示了 BIN1 剪接异构体在心脏 T 小管形态发生中的互补作用。 Bridging integrator...