Eighteen purpose-bred, specific-pathogen-free, male, neutered domestic shorthair cats (Felis catus), 1-2 years of age, were trained and tested to a T-maze protocol using food rewards. The test protocol consisted of positional discrimination training (left arm or right arm) to criterion ...
This protocol details a method for using a T-maze to assess the cognitive ability of rodents. The T-maze is an elevated or enclosed apparatus in the form of a T placed horizontally. Animals are started from the base of the T and allowed to choose one of the goal arms abutting the ...
Another protocol used with the T-Maze is the Delayed Alternation task. The Delayed Alternation task allows assessing spatial working memory by first allowing the subject to explore a baited arm of its choice and removing the subject once the choice is made and limiting it to the start box of...
Colwill et al. (2005)developed a different experimental protocol using a T-maze to assess memory acquisition, extinction, and reversal in adult zebrafish. The 1st stage of the test was pretraining, where each fish was exposed to the food reward (US) in theabsenceof the CS color cue (4 ...
(usually from 5 to 12, depending on the protocol), with an intertrial interval (ITI) that can range from virtually zero to 20, 40 or even 60 s. Percentages of alternation across the test trials are calculated as an index of working memory. Healthy wild-type animals generally display a ...
A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's Disease Alzheimer's disease is a progressive neurodegenerative disease that manifests as memory loss, cognitive dysfunction, and dementia. Animal models of Alzheim... A ...
Bio-protocol Semantic Scholar dx.doi.org NCBI ResearchGate 相似文献Entorhinal-perirhinal lesions impair performance of rats on two versions of place learning in the Morris water maze. The effects of entorhinal-perirhinal lesions in rats were studied with 2 versions of a place learning task in the...
This protocol details a method to perform appetitively motivated tasks in rodents to test cognitive ability. When testing cognition in animals, the simplest paradigms can potentially yield quick results with minimal investment from the experimenter. Although appetitively motivated tasks are generally ...
The University of Guelph Animal Care Committee considered and approved the use of animals and its ethicality (Animal Utilization Protocol #4127). Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared ...
This protocol details a method to perform appetitively motivated tasks in rodents to test cognitive ability. When testing cognition in animals, the simplest paradigms can potentially yield quick results with minimal investment from the experimenter. Although appetitively motivated tasks are generally ...