Functionally, Th2 cytokines have effects on many cell types in the body as the cytokine receptors are widely expressed on numerous cell types. Th2 cells stimulate and recruit specialized subsets of immune cells, such as eosinophils and basophils, to the site of inf...
Poholek and colleagues show that, during allergic airway inflammation, the transcription factor Blimp-1 regulates CD4+TH2 cell migration to the lung and define anatomical locations in mediastinal lymph nodes where IL-2 programming induces TH2 cell polarization. ...
Th2细胞(T helper 2 cell) 在IL-4的作用下由Th0细胞分化而来,主要作用是诱导和促进B细胞介导的体液免疫应答,在变态反应及抗寄生虫感染中也发挥重要作用,能够抑制Th1细胞的增殖。主要分泌IL-4、IL-5、IL-6、IL-10等细胞因子,主要的转录因子是GATA3。 常用Marker Human 克隆号 可选标记 规格 CD4 RPA-T4 ...
(g–i) Quantification of CD49d+ Th2 cells (g) and eosinophils (h) in ΔneoTreg and ΔadTreg mice during the inflammatory phase of Treg reduction at 10 days post-DT. Myeloid cell localization in ΔneoTreg mice (i) was quantified by flow cytometry of dissected skin layers. n = ...
3.2.2 Cell-mediated immunity mediated by decellularized materials Upon stimulated by antigens, CD4+ T helper cells differentiate into T helper 1 (TH1) cells and T helper 2 (TH2) cells [111]. TH1 cells are characterized by the production of pro-inflammatory cytokines, including tumor necrosis ...
Ochi H, Hirani WM, Yuan Q, et al: T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med 1999;190:267-280.Ochi H, Hirani WM, Yuan Q, et al. T helper cell type 2 cytokine- mediated comitogenic...
GATA-binding protein 3 (Gata3) controls the differentiation of naive CD4 T cells into T helper 2 (Th2) cells by induction of chromatin remodeling of the Th2 cytokine gene loci, direct transactivation of Il5 and Il13 genes, and inhibition of Ifng. Gata3 also facilitates Th2 cell proliferat...
Two functionally distinct CD4+T cellsubsets, T helper 1 (Th1) and T helper 2 (Th2), distinguishable by the pattern of cytokines they produce upon stimulation, have been described in the late 1980s (Mosmann and Coffman, 1989). Th1 cells are characterised by secretion of IFN-γ and lympho...
Tsuyuki S, Tsuyuki J, Einsle K, Kopf M, Coyle AJ: Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J Exp Med 1997, 185 : 1671-1679. PubMed Abstract Publishe...