Michallet AS, Lesca G, Radford-Weiss I, Delarue R, Varet B, Buzyn A (2003) T-cell prolymphocytic leukemia with autoimmune manifestations in Nijmegen breakage syndrome. Ann Hematol 82: 515–517.Michallet AS, Lesca G, Radford-Weiss I, Delarue R, Varet B, Buzyn A. T-cell pro...
T-cell prolymphocytic leukemia (T-PLL) is an aggressive mature T cell neoplasm that typically involves peripheral blood, bone marrow, lymph nodes and spleen. It is a rare disease that comprises 2-5% of mature lymphocytic leukemia in adults. Here we present a T-PLL patient with CNS involvemen...
The clinical course of a patient with extensive skin involvement due to T-cell prolymphocytic leukemia is described. The malignant cells isolated from the patient's blood and skin were studied utilizing cytochemical analysis and multiple monoclonal antibodies directed against cell surface antigens. The...
Examines the effectiveness of nonmyeloablative allogeneic stem cell transplantation in treating patients with T-prolymphocytic leukemia (T-PLL). Clinical manifestations of T-PLL; Method used in treating hematologic malignancies; Association of fludarabine with busulfan and a...
Article: Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogeneous with a wide range of clinical, ...
T-cell Prolymphocytic Leukemia (T-PLL) is a mature post-thymic T-cell malignancy with aggressive clinical course. The principal disease characteristics are organomegaly, skin lesions and raised lymphocyte counts. We report two cases of T-PLL. T-PLL is a rare T-cell malignancy with characteristi...
Abstract The majority of published cases of prolymphocytic leukemia (PLL) have been of B‐cell origin. Nineteen cases of PLL of T‐cell type have been described, as has a single case of PLL having a surface phenotype with features of both B‐cells and T‐cells. This report presents a re...
Patients were treated with various chemotherapy regimens but with poor outcome, the median survival being 13 months. Laboratory and clinical data suggest great similarity between Sezary cell leukaemia and T prolymphocytic leukaemia (T-PLL), namely co-expression of CD4 and CD8 (3/9 cases), ...
Multiple karyotypic abnormalities in three cases of small cell variant of T-cell prolymphocytic leukemia. Cancer Genet Cytogenet. 1994 Nov;78(1):28-35Kristiina Heinonen, Eija Mahlamäki, Esa Hämäläinen, Tapio Nousiainen, Ilkka Mononen. (1994) Multiple karyotypic abnormalities in three ...