Express low voltage-activated (LVA), T-type, Ca2+Channel (Cav) 3.1, 3.2, or 3.3 All cDNAs of human origin Cav3.x expression is under G418 selection (0.4 mg/ml maintenance, 1 mg/ml to prepare frozen aliquots) Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium...
T-type Ca2+ channelSmooth muscleVascular diseaseProliferationT-type Ca2+ channels regulate proliferation in a number of tissue types, including vascular smooth muscle and various cancers. In such tissues, up-regulation of the inducible enzyme heme oxygenase-1 (HO-1) is often observed, and hypoxia...
www.nature.com/scientificreports OPEN Ca-α1T, a fly T-type Ca2+ channel, negatively modulates sleep received: 11 August 2015 accepted: 06 November 2015 Published: 09 December 2015 Kyunghwa Jeong1, Soyoung Lee2, Haengsoo Seo2,Yangkyun Oh1, Donghoon Jang1, Joonho Choe1, ...
The density of T-type Ca2ϩ channels is predominant only in pacemaker cells of the sino- atrial node and the Purkinje fibers (15,16). The physiologic role of the T-type Ca2ϩ channel has been postulated to be involved in the cell cycle during proliferation (17); therefore, we expect...
Among the major families of voltage-gated Ca2+ channels, the low-voltage-activated channels formed by the Cav3 subunits, referred to as T-type Ca2+ channel
T-type Ca2+ channels (CACNA1G, CACNA1H, and CACNA1I genes; Cav3.1, Cav3.2, and Cav3.3 channel α subunits, respectively) are a family of voltage-gated Ca2+ channels with very negative activation thresholds (less than −60 mV) and fast inactivation kinetics (1, 2). The channels are...
Ca2+ channel:钙离子通道a) Gated by voltage:电压门控钙离子通道根据钙通道传导性和对电压敏感性的不同,又进一步分为L、T、N三种亚型。不同V
type Ca2+channel on cervical cancer cell growth. Methods We chose Siha cells wh Results SiRNA against Cav3.1/3.2 knocked down the expression of T-type Ca2+channels specifically and effectively.Small iIlterf舐ng RNA inhibited Siha cells proliferation (P<O.01).Retard cell cycle at GO—G1 phase...
Distinct contributions of different structural regions to the current kinetics of the Cav3.3 T-type Ca2+ channel Kang HW,Park JY,Lee JH.Distinct contributions of different structural regions to the current kinetics of the Cav3.3 T-type Ca2+ channel. Biochimica et ... HW Kang,JY Park,JH Lee...
Translational research of t-type ca2+ channel stimulator as Alzheimer disease therapeuticsDehydroepiandrosterone (DHEA) is the most abundant neurosteroid synthesized de novo in the central nervous system. Oral DHEA administration elicits ... K Fukunaga,Y Yabuki,Y Shinoda,... - 《Alzheimers & Dementia...