This time, we incubated the cells in vitro in the presence of the ACLY inhibitor BMS-303141 or DMSO for 3 h. Next, we sorted eGFP+ cells by flow cytometry and performed ATAC-seq and transcription factor footprint analysis. In agreement with the ex vivo results (Fig. 5a), we detected...
human epidermal growth factor receptor 2 (HER2)-low or HER2-ultralow metastatic breast cancer (mBC) with prior endocrine therapy (ET): Primary results from DESTINY-Breast06 (DB-06). 2024 ASCO. LBA
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Such calculations for heavy quarkonia will be performed for the first time. The paper is organized as follows. In Sect. 2 we briefly describe our theoretical framework and basic steps of our calculation. In Sect. 3 we present the numerical results and discussion. Section 4 sums up our ...
6g,h), although this waned over time (Extended Data Fig. 7i,j). These phenotypes correlated with a significant decrease in both SA-β-gal-positive and uPAR-positive cells in pancreas, liver and adipose tissue (Fig. 6i and Extended Data Fig. 7k–p). Taken together, these results show ...
Area under the concentration-time curve CC: Column chromatography Cmax : Maximum concentration achieved H E: Hematoxylin and eosin HTX: 1-Hydroxy-5,6,7-trimethoxyxanthone ICR: Institute of Cancer Research IP: Intraperitoneal LC-MS/MS: Liquid chromatography triple quadrupole mass spectrometry...
It's about time we got a new dystopian TV show to obsess about, and Silo is all too happy to fill that void. Imagine, if you will, that you are one of the last 10,000 people on Earth. You live in a mile-deep underground silo that protects you from whatever toxic horrors await ...
36_It takes time to learn how to prevent your tendency to laugh, but distraction is an easy way to stop yourself, in the meantime. Try one of these options for shifting your thoughts away from what's setting off y...
SOSIP/3M-052 vaccination induced robust half-maximum infectious dose (ID50) titers of autologous nAbs to BG505.T332N Env pseudovirus (Fig.1d,e). We first analyzed sera from baseline and peak time points, 2 weeks after each vaccination. In both vaccine groups, nAb titers were first detected...
Results Near-fault coseismic displacements from the strong-motion data The availability of dense near-fault strong-motion observations presents an excellent opportunity to study the detailed rupture processes of the 2023 Türkiye earthquake doublet. Near-field static deformation provides robust constraints ...