另一个亚群Tfh(卵泡辅助性T细胞)促进B细胞的抗原特异性发育并分泌IL-21。滤泡辅助性T细胞(T follicular helper cells, Tfh),是体液免疫中辅助B细胞产生抗体的T细胞亚群。在淋巴组织的T细胞区被抗原激活,然后迁移到B细胞卵泡的外缘,在这里遇到抗原特异性B细胞...
HIV Helper T-cell EpitopesEpitopes, H I V Helper Tcell
滤泡辅助性T(Follicular helper T,TFH)细胞是CD4+ T细胞的一个特殊亚群,表达趋化因子受体CXCR5,主要支持生发中心(germinal center, GC)反应,在生发中心反应中产生高亲和力和长期的体液免疫,调节记忆性和抗体分泌性B细胞的克隆选择和分化,从而控制抗体记忆和亲和力成熟。 其在...
1、辅助性T细胞(Helper T cells,Th),具有协助体液免疫和细胞免疫的功能; 2、抑制性T细胞(Suppressor T cells,Ts),具有抑制细胞免疫及体液免疫的功能; 3、效应T细胞(Effector T cells,Te),具有释放淋巴因子的功能; 4、细胞毒性T细胞(Cytotoxic T cells,Tc),具有杀伤靶细胞的功能; 5、迟发性变态反应T细胞(Delaye...
Acquired immune deficiency syndrome (AIDS) is a disease caused by destruction of helper T-cells (T4) by the virus HTLV-III or HIV (human immunodeficiency virus). From:Illustrated Physiology (Sixth Edition),1990 Also in subject areas:
CD4-positive T cells are a subtype of lymphocyte. They are MHC class II-restricted and are important mediators of adaptive immunity. These cells are involved in both the induction and the restraint of most immunological functions. A key element in the profound immunosuppression seen in HIV infecti...
During chronic HIV infection, viral replication is highly concentrated within B-cell follicles in follicular T helper cells (TFH)3–5. TFH are crucial initiators of the germinal centre (GC) response6,7. TFH have a distinct developmental pathway characterized by Bcl-6 expression, which is ...
然而，在HIV等慢性感染以及肿瘤微环境中，CD4+ T细胞的辅助功能失调，无法为CD8+ T细胞提供有效的帮助【14,15】。BATF被认为是IL-21信号通路主要的下游转录因子【16】，因此，以BATF为靶点编辑T细胞可以绕过对CD4+ T-IL-21的需求，直接阻断祖细胞向耗竭T细胞分化的可能，促进其向效应T细胞分化。从而增强T细胞抗病毒...
T Cells: Primary Effectors for Cell-Mediated Immunity TheT cellis the primary effector for control and regulation of adaptive immune function. T helper 1 (TH1) cells aid in the regulation ofcellular immunity. T helper 2 (TH2) cells aid B cells inisotypeswitching and in production of antibodi...
经过近十年的研究,特别是谱系转录因子Bcl6的发现,这些分子作为TFH的细胞标志物被广泛接受。自此,多项研究表明滤泡辅助性T细胞(Follicular helper TTFH)对于病原体清除和疫苗介导的保护性抗体反应至关重要。但是异常或者过度的TFH细胞反应会促进淋巴瘤...