滤泡辅助性T(Follicular helper T,TFH)细胞是CD4+ T细胞的一个特殊亚群,表达趋化因子受体CXCR5,主要支持生发中心(germinal center, GC)反应,在生发中心反应中产生高亲和力和长期的体液免疫,调节记忆性和抗体分泌性B细胞的克隆选择和分化,从而控制抗体记忆和亲和力成熟。 其在...
Tfh细胞(Follicular helper T cell)是参与体液免疫的辅助性T细胞亚群,直接来源于初始T细胞,存在于扁桃体、淋巴结等淋巴组织中。Tfh细胞分泌细胞因子刺激B细胞增殖以及免疫球蛋白的转换,通过刺激生发中心(GC),B细胞分化成为浆细胞和记忆B细胞,参与体液免疫。并且Tfh细胞通过分泌IL-21增强CD8+T细胞功能,参与细胞免疫。 研...
滤泡辅助性T细胞(T follicular helper cells, Tfh),是体液免疫中辅助B细胞产生抗体的T细胞亚群。在淋巴组织的T细胞区被抗原激活,然后迁移到B细胞卵泡的外缘,在这里遇到抗原特异性B细胞。 这类抗体反应发生在淋巴滤泡的生发中心(GC),需要抗原特异性B和Th细胞之间的相互作用。将Tfh细胞归巢到GC依赖于两步趋化过程,这...
T follicular helper (Tfh) cells are a specialized subset of CD4 + T cells that support B cell responses in germinal centers (GC). Tfh development is initiated when antigen-presenting cells provide signals that trigger differentiation toward the Tfh state through the induction of key transcription ...
What is a T follicular helper (Tfh) cell? T follicular helper (Tfh) cells are a subset of CD4-positive T helper cells that are involved in the humoral response [1]. Tfh cells are found in secondary lymphoid tissues, including tonsils, spleen, and l...
What is a T follicular helper (Tfh) cell? T follicular helper (Tfh) cells are a subset of CD4-positive T helper cells that are involved in the humoral response [1]. Tfh cells are found in secondary lymphoid tissues, including tonsils, spleen, and ...
Tfh细胞(Follicular helper T cell)是参与体液免疫的辅助性T细胞亚群,直接来源于初始T细胞,存在于扁桃体、淋巴结等淋巴组织中。Tfh细胞分泌细胞因子刺激B细胞增殖以及免疫球蛋白的转换,通过刺激生发中心(GC),B细胞分化成为浆细胞和记忆B细胞,参与体液免疫。并且Tfh细胞通过分泌IL-21增强CD8+T细胞功能,参与细胞免疫。
T follicular helper (Tfh) cells are the main T helper (Th) cell subset that provides help to B cells, supporting germinal center induction, affinity maturation, and generation of memory B cells and long-lived plasma cells. Recently, Tfh cells and Tfh-like transition states have also been ...
What is a T follicular helper (Tfh) cell? T follicular helper (Tfh) cells are a subset of CD4-positive T helper cells that are involved in the humoral response [1]. Tfh cells are found in secondary lymphoid tissues, including tonsils, spleen, and lymph nodes. The role of Tfh cells is...
简介:滤泡辅助性T细胞( Follicular helper T cell, Tfh )是由 Schaerli 和 Breifeld 在2000年发现的,且在2008年 King 等人确定了 Tfh 细胞是一种独立的 CD4+T 效应细胞亚群。Tfh细胞直接来源于初始T细胞(Naïve T cells),定位于**滤泡,主要功能是辅助B细胞增殖和产生抗体,参与体液**。它对**系统的建立以...