T follicular helper (Tfh) cells are the main T helper (Th) cell subset that provides help to B cells, supporting germinal center induction, affinity maturation, and generation of memory B cells and long-lived plasma cells. Recently, Tfh cells and Tfh-like transition states have also been ...
T follicular helper (TFH) cells are critical in adaptive immune responses to pathogens and vaccines; however, what drives the initiation of their developmental program remains unclear. Studies suggest that a T cell antigen receptor (TCR)-dependent mechanism may be responsible for the earliest TFH ce...
Th22参与了在银屑病,强直性脊柱炎、桥本甲状腺炎,和多发性硬化症。 另一个亚群Tfh(卵泡辅助性T细胞)促进B细胞的抗原特异性发育并分泌IL-21。滤泡辅助性T细胞(T follicular helper cells, Tfh),是体液免疫中辅助B细胞产生抗体的T细胞亚群。在淋巴组织的T细胞...
Follicular helper T (Tfh) cells provide help to B cells and allow formation of long-livedantibody responses. Despite an improved understanding of the molecular program that drives Tfh cell formation, their definition remains elusive: neither follicular homing ability, Bcl-6 expression nor IL-21 secr...
滤泡辅助性T(Follicular helper T,TFH)细胞是CD4+ T细胞的一个特殊亚群,表达趋化因子受体CXCR5,主要支持生发中心(germinal center, GC)反应,在生发中心反应中产生高亲和力和长期的体液免疫,调节记忆性和抗体分泌性B细胞的克隆选择和分化,从而控制抗体记忆和亲和力成熟。
regulatory T cells; SLE: systemic lupus erythematosus; CNS: central nervous system; Tfh: T follicular helper; dMLN: distal part of mesenteric LN; BM: bone marrow; S1P: sphingosine-1 phosphate; S1PR: sphingosine-1 phosphate receptor; mo-DCs: monocyte-derived DCs; HTLV: human T-cell leukemia...
What is a T follicular helper (Tfh) cell? T follicular helper (Tfh) cells are a subset of CD4-positive T helper cells that are involved in the humoral response [1]. Tfh cells are found in secondary lymphoid tissues, including tonsils, spleen, and ...
Follicular helper T-cell memory: establishing new frontiers during antibody response. Immunol Cell Biol. 2014; 92:57-63.Tsai LM, Yu D. Follicular helper T-cell memory: establishing new frontiers during antibody response. Immunol Cell Biol (2014) 92:57-63. doi:10.1038/ icb.2013.68...
Tfh细胞(Follicular helper T cell)是参与体液免疫的辅助性T细胞亚群,直接来源于初始T细胞,存在于扁桃体、淋巴结等淋巴组织中。Tfh细胞分泌细胞因子刺激B细胞增殖以及免疫球蛋白的转换,通过刺激生发中心(GC),B细胞分化成为浆细胞和记忆B细胞,参与体液免疫。并且Tfh细胞通过分泌IL-21增强CD8+T细胞功能,参与细胞免疫。
What is a T follicular helper (Tfh) cell? T follicular helper (Tfh) cells are a subset of CD4-positive T helper cells that are involved in the humoral response [1]. Tfh cells are found in secondary lymphoid tissues, including tonsils, spleen, and lymph nodes. The role of Tfh cells is...