小编认为本研究的结果不仅有利于临床上Treg和Tconv细胞的准确分选,也为我们进行单细胞测序细胞亚群的注释提供了思路。 [参考文献] Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A. Distinguishing activated T regulatory cell and T conv...
由于 pTreg 在Foxp3基因表观修饰和效应分子表达上稳定性更差,并不适合作为细胞治疗的原料;而通过初始 CD4 阳性 T 细胞(Naïve CD4+T 细胞)诱导得到的 iTreg 细胞以及 tTreg 细胞,在体外也具有良好的增殖能力和稳定的抑制功能,...
In conclusion, Treg-cell depletion increases the accumulation of conventional T cells in intestinal tumors, and targeting Treg cells could be a possible anti-tumor immunotherapy, which not only affects T-cell effector functions, but also their recruitment to tumors. 展开 ...
conventional tcellh 传统的tcellh conventional 英[kənˈvenʃənl] 美[kənˈvɛnʃənəl]adj. 传统的; 习用的，平常的; 依照惯例的; 约定的;[网络] 约定; 规约性; 惯用;[例句]It is simpler and quicker to use ...
The current investigation revealed a marked differential expansion of CD4(+) T cell subsets. Successful immunotherapy surprisingly resulted in an expansion of CD4(+)Foxp3(+) regulatory T (Treg) cells concurrent with a reduction of conventional CD4(+) T (Tconv) cells, despite the marked ...
cell细胞. 根据语境及常识可知,种子在地下会一直处在黑暗 中.句意:如果我把根扎进地下,我不知道我会在 黑暗中遇到什么.故选B. 42.A .考查推理判断.A.hard坚硬的;B.da mp潮湿的;C. thin稀少的;D. loose松的. 根据下文"I may damage my delicate sprout s"(我可能会伤害我娇嫩的幼芽)可推测,泥土...
细胞朊病毒蛋白在淋巴细胞中表达并被认为是T细胞活化抗原。此外，调节性T细胞的转录过程研究，已经显示细胞朊蛋白优先超表达，意味着它可能在调节功能上有重要作用。在小鼠体内，与CD4+CD25-细胞相比，CD4+CD25+调节性T细胞无论是朊病毒蛋白信息表达还是细胞表面细胞朊病毒蛋白水平上都有所增加。然而，PrP0/0小鼠没有...
Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells. Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2þ), NF-kappaB, and NFAT signaling in conventional T cells. Sci Signal 2011;4:... A Schmi...
CCR3染色则用于识别上呼吸道粘膜中蓄积并参与哮喘和过敏性炎症的 T 细胞。 最后,方案中还纳入了CCR5,其表达在多种病理过程(包括自身免疫、癌症和 HIV 感染)的活化 T 细胞上,并与 CXCR3 结合,促使T细胞形成自身免疫性疾病的炎性改变...
This was accompanied by decreased expression of T(r) cell 'signature genes'. Notably, T cells expressing decreased Foxp3 preferentially became T-helper 2 (T(h)2)-type effectors even in a T(h)1-polarizing environment. These cells instructed T(h)2 differentiation of conventional T cells, ...