上期文章《 细胞免疫研究的核心通路——T cell receptor signaling pathway(上) 》中,介绍了TCR信号通路的结构、相关膜表面蛋白及通路主要过程,今天继续分享TCR信号通路的关键调节结点、T细胞发育过程中的TCR信号通路调节、CD28超家族的共刺激/抑制作用。 一、TCR信号通路的关键调节结点 1.1 LCK结点的调节 酪氨酸激酶LCK...
上期文章《细胞免疫研究的核心通路——T cell receptor signaling pathway(上)》中,介绍了TCR信号通路的结构、相关膜表面蛋白及通路主要过程,今天继续分享TCR信号通路的关键调节结点、T细胞发育过程中的TCR信号通路调节、CD28超家族的共刺激/抑制作用。 一、TCR信号通路的关键调节结点 1.1 LCK结点的调节 酪氨酸激酶LCK是...
我们先来看看TCR信号通路在kegg通路中的位置。在前文提到的kegg核心35通路中(下图),TCR信号通路一共与7个通路存在直接串扰关系(包括上下游连接关系或者平行串扰关系)。TCR信号通路核心是TCR与配体、共受体等的互作以及相关的调控关系。但该通路的信号最终还是依赖我们熟悉的NF-κB、MAPK、Calcium signaling pathway等通路...
Map of the T-cell receptor signaling pathway, as generated by KEGG.The PLOS ONE Staff
KEGG pathway analysis provides further insight into mechanisms that support CD4 T-cell migration and activity. These include upregulation of the leukocyte transendothelial migration pathway (gene ratio: 0.0417, Padj = 7.332E−11) [45], NF-kappa B signaling pathway (gene ratio: 0.0359 Padj...
JAK-STAT signaling is an important regulatory pathway and a plausible candidate for controlling immune cell homeostasis. Building upon decades of research on JAK-STAT signaling in immunology and development22,23, recent studies utilized RNA sequencing (RNA-seq) and epigenome profiling to investigate JAK...
Non-Hodgkin lymphoma (NHL) is a common malignancy in the hematologic system, and traditional therapy has limited efficacy for people with recurrent/refractory NHL (R/R NHL), especially for patients with diffuse large B cell lymphoma (DLBCL). Chimeric antigen receptor (CAR) T-cell therapy is a...
KEGG termGene count%p Value Ribosome 14 1.9 4.0 × 10−5 Primary immunodeficiency 9 1.2 6.1 × 10−5 Hematopoietic cell lineage 13 1.7 9.9 × 10−5 Cytokine–cytokine receptor interaction 20 2.7 3.4 × 10−3 GnRH signaling pathway 11 1.5 4.7 × 10−3 Leukocyte transendothelial migrati...
3B). Similarly, T cell receptor signaling, CD28 signaling in T helper cells and Interferon alpha/beta signaling pathway also stood out according to KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis (Fig. 3 C). Consistent with the above GO and KEGG results, the GSEA (Gene Set...
FIG. 9B provides a summary of normalized enrichment scores (NES) of KEGG pathways with p<0.05 that were enriched in the comparison of two eTreg cell strains indicated following gene set enrichment analysis (GSEA). Blue bars are pathways enriched in the baseline eTregs and red bars are pathway...