T- cell Prolymhocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy that is usually reported in the elderly and follows an aggressive course. A 68 year old male presented with a history of weakness and weight loss of two months duration. Clinical examination revealed ...
简介T淋母细胞(Tcellprolymphocyticleukemia,T-PLL)是一种罕见但具有侵袭性的造血系统恶性肿瘤,其特点是成熟的T淋巴母细胞在外周血液中的异常增生。传统的治疗方法包括化疗、放疗和干细胞移植等,并且疗效较差。然而,近年来,新的治疗方法和药物的开发为T-PLL的治疗带来了新的希望。本文将介绍现阶段常用的T淋母细胞淋...
It needs to be differentiated from B-Cell prolymphocytic leukemia (B-PLL) and other mature T-cell lymphoproliferative disorders with predominant leukemic pattern. Differentiation can be made by a comprehensive approach taking into account the clinical features, the cell morphology and the immunophenotype...
T-cell prolymphocytic leukemia (T-PLL) is an aggressive mature T cell neoplasm that typically involves peripheral blood, bone marrow, lymph nodes and spleen. It is a rare disease that comprises 2-5% of mature lymphocytic leukemia in adults. Here we present a T-PLL patient with CNS involvemen...
Keywords: T-prolymphocytic leukemia (T-PLL);TCL1A;ATM;alemtuzumab;T-cell receptor;JAK;STAT;BH3 mimetic
T-cell prolymphocytic leukemia (T-PLL) is a postthymic T-cell neoplasm with a characteristic morphology and heterogeneous immunophenotype. Most cases of T-PLL express membrane T-cell receptors (TCRs) of the alphabeta phenotype. We experienced a 30-year-old man suffering from TCRgammadelta T-...
T prolymphocytic leukemia (T-PLL) is an unusual disease characterized by high white cell counts, older age at presentation, splenomegaly and a very aggressive clinical course. We describe a 47-year-old male with refractory T-PLL who was treated with high-dose chemoradiotherapy and allogeneic ...
Multiple karyotypic abnormalities in three cas- es of small cell variant of T-cell prolymphocytic leukemia. Cancer Genet Cytogenet 1994; 78:28-35.Heinonen K, Mahlamaki E, Hamalainen E, Nousiainen T, Mononen I. Multiple karyotypic abnormalities in three cases of small cell variant of T-...
T cell Prolymphocytic Leukemia (T-PLL) is a rare and aggressive mature T cell Lymphocyte Leukemia. Twenty five percent of cases present as a small cell variant, and only 5% as a cerebriform variant. We report a 58 year-old man with rapidly progressive severe leukocytosis, skin lesions, lym...
We describe two patients with T cell prolymphocytic leukemia (T-PLL) who exhibited the same complex karyotype, including an additional segment at 1p36.1. One presented with secondary progression following an initial stable clinical course, and the other with typically progressive disease. Features of...