These are T-lymphoblastic lymphoma, a tumour of precursor T-cells that is dealt with in Chapter 10, chronic lymphocytic leukaemia of T-cell type and the cutaneous T-cell lymphomas (mycosis fungoides and Sezary's syndrome). Numerous histological subtypes of node-based T-cell lymphomas have been...
早在1973年,T幼淋巴细胞白血病(T-cell prolymphocytic leukemia, T-PLL)就因临床特异性表现、受累淋巴细胞形态特征及较差的预后而被认为与慢性淋巴细胞白血病(chronic lymphocytic leukemia, CLL)不同[1]。现代肿瘤学见证了越来越多有效的新型抗肿瘤药物的...
• Peripheral T-Cell Lymphomas (PTCL-1) • Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIAA-INTRO) • T-Cell Large Granular Lymphocytic Leukemia (LGLL-INTRO) • T-Cell Prolymphocytic Leukemia (TPLL-1) • Adult T-Cell Leukemia/Lymphoma (ATLL-1) ...
B-prolymphocytic leukemia and prolymphocytic variant of mantle cell lymphoma are of B-cell lineage with their own characteristic immunophenotypic features. The neoplastic cells of Sezary syndrome (SS) often lack CD7 expression, whereas T-PLL cells are typically CD71. The tumor cells of adult T-...
Two patients had a CD4/CD8 ratio exceeding 10, but without an increase in CD4+ cells: one patient had SS with coexisting B-cell chronic lymphocytic leukemia, the other patient only had a depressed CD8 count. In addition, many of the cases had evidence of phenotypically abnormal T cells by...
2022年12月12日,来自美国宾夕法尼亚大学的Daniel J. Powell研究组在Cancer Cell上发表题为Expression of inducible factors reprograms CAR-T cells for enhanced function and safety的文章,将上述单载体思路进行了转化。 为了将上述思路用于临床,作者首先搭建了...
Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B cells has proven to be a successful treatment for B cell malignancies. This success inspired the development of CAR T cells to selectively deplete or modulate
Extended Data Table 1 Abbreviations: Axi-cel: axicabtagene ciloleucel; Brexu-cel: brexucabtagene autoleucel; Ide-cel: idecabtagene vicleucel; LBCL: large B cell lymphoma; MCL: mantle cell lymphoma; MDS: myelodysplastic syndrome; MM: multiple myeloma; NSCLC: non-small cell lung cancer;...
Cogent data on allogeneic haematopoietic stem-cell transplantation efficacy in advanced cutaneous T-cell lymphoma. Lancet. 2023 Jun 10;401(10392):1906-1907. doi: 10.1016/S0140-6736(23)00631-1. Epub 2023 Apr 24. PMID: 37105211. [21] Schett G, Mackensen A, Mougiakakos D. CAR T-cell ...
4. Tonino, S. H. et al. Expansion of Effector T Cells Associated with Decreased PD-1 Expression in Patients with Indolent B Cell Lymphomas and Chronic Lymphocytic leukemia. Leuk.Lymphoma 2012, 53(9), 1785–94 5. van Bruggen, J. A. C. et al. Chronic Lymphocytic Leukemia Cells Impair ...