Ivashkiv LB, Zamarin D, Cantillo E, Chapman-Davis E, Holcomb K, Morales DK, Yu X, Rodriguez PC, Conejo-Garcia JR, Kaczocha M, Vähärautio A, Song M, Cubillos-Ruiz JR.guards T cell lipid metabolism and antitumour function
Lipid metabolism has emerged as a key regulator of T cell responses, with selective lipid metabolites serving as metabolic rheostats to integrate environmental cues and interplay with intracellular signaling processes. Here, we discuss how extracellular, de novo synthesized and membrane lipids orchestrate ...
他们的研究结果发表在《Cell Metabolism》杂志上的一篇题为“Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment”的文章中。该研究小组由Jessica Thaxton博士领导,她是UNC Lineberger综合癌症中心细胞生物学和生理学副教授,也是癌细胞生物学项目的共同负责人。由公共卫生硕士Kat...
此外,免疫抑制性CD4+调节性T细胞(Treg)在T细胞发育过程中形成,或由原始T细胞生成,以维持自我耐受性,这对预防自身免疫反应至关重要,但对肿瘤的根除起到了制动作用。2022年SeonAh Lim等人于《Nature Chemical Biology》杂志发表了一篇名为...
et al. Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function. Cell Metab. 31, 422–437.e425 (2020). Article CAS PubMed PubMed Central Google Scholar Wang, H. et al. CD36-mediated metabolic adaptation supports regulatory T cell ...
5. C. D'Souza-Schorey, P. Chavrier. ARF proteins: roles in membrane traffic and beyond.Nat Rev Mol Cell Biol2006; 7:347-358. 6. G. Wang et al. Arf1-mediated lipid metabolism sustains cancer cells and its ablati...
We will also describe how the modulation of lipid metabolism can be used as a strategy for modulation of T cell differentiation. 7.1. Regulation of T cell differentiation by mTOR mTOR was first discovered as the cellular target of rapamycin [89], a Streptomyces–derived compound which is ...
文章题目：Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development 发表杂志：NATURE CELL BIOLOGY IF：17.3 2024 脂质对于能量储存、膜结构和细胞信号传导是不可或缺的。然而，哺乳动物早期胚胎发育中各种内源性脂质的动态变化尚未得到系统表征。在这里，文章全面研究了小鼠...
近日,来自美国德克萨斯大学医学中心(UT Health)的Elizabeth A. Leadbetter团队在Cell Metabolism上在线发表题为T-bet+B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity的文章,描述了T-bet+B细胞在肥胖加剧代谢紊乱和糖尿病症状中的作用,阐明了T-bet+B细胞在小鼠和人类的进行性肥胖...
文章题目:Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development 发表杂志:NATURE CELL BIOLOGY IF:17.3 2024 脂质对于能量储存、膜结构和细胞信号传导是不可或缺的。然而,哺乳动物早期胚胎发育中各种内源性脂质的动态变化尚未得到系统表征。在这里,文章全面研究了小鼠和人类...