In many respects, much less is known of the T cell leukaemias and lymphomas then the B cell malignancies, and it is only recently that they have been studied in the detail previously accorded the B cell neoplasms. The classification of T cell malignancies is even more controversial than the ...
Human T-cell leukaemias and lymphomas associated with the human T-cell leukaemia viruses (HTLV) 1–3 are invariably neoplasms of cells with mature T-lymphocyte phenotype 4,5 . Epstein–Barr virus-transformed B-lymphocyte lines which are productively infected with HTLV may be isolated from patients...
Antibody and chimeric antigen receptor (CAR) T cell-mediated targeted therapies have improved survival in patients with solid and haematologic malignancies1,2,3,4,5,6,7,8,9. Adults with T cell leukaemias and lymphomas, collectively called T cell cancers, have short survival10,11 and lack such...
Antibodies to HTLV-I in Nigerian blood-donors, their relatives and patients with leukaemias, lymphomas and other diseases Int. J. Cancer, 38 (Dec (6)) (1986), pp. 809-813 CrossrefView in ScopusGoogle Scholar [29] A. Paiva, J. Casseb Sexual transmission of human T-cell lymphotropic viru...
Heterogeneity of T-cell beta-chain gene rearrangements in human leukaemias and lymphomas. The state of T-cell receptor beta-chain gene rearrangement in human T-cell leukaemias has been analysed. All forms of leukaemia tested (T-CLL, ALL, PLL, Sezary syndrome and ATL) exhibit rearrangements of ...
The selectivity of a monoclonal anti-T antibody, designated WT1, has been assessed in a series of 906 leukemias and lymphomas. In acute lymphoblastic leukemias, WT1 reacts comprehensively and selectively with thymic acute lymphoblastic leukemia (ALL) cells in untreated or relapsed patients, thus ...
CAR (Chimeric Antigen Receptor) T cells have demonstrated clinical success for the treatment of multiple lymphomas and leukaemias, but not for various solid tumours, despite promising data from murine models. Lower effective CAR T-cell delivery rates to human solid tumours compared to haematological ...
Deoxycoformycin in the treatment of mature T-cell leukaemias. We describe the results of treatment with 2'-deoxycoformycin (DCF) in 68 patients with post-thymic (mature) T-cell malignancies. These included: prolymphocytic leukaemia (T-PLL), 31, HTLV-1 + adult T-cell leukaemia/lymphoma (...
predominant majority of aggressive NK-cell leukemia is EBV-positive, a series of seven cases of EBV-negative aggressive NK-cell leukaemia had been reported recently [31]. In two of these cases,STAT3mutations were found. The pathogenetic mechanisms of EBV-negative NK-cell leukaemias remain to be...
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of