T细胞大颗粒淋巴细胞白血病(T cell large granular lymphocyte leukemia, T-LGLL)是具有细胞毒性的T淋巴细胞克隆性增殖所致的一种罕见淋巴增殖性疾病,以不同程度的血细胞减少和自身免疫性疾病发生为主要特点。以往研究提出,慢性抗原刺激与体细胞STAT3突变共...
T细胞大颗粒淋巴细胞白血病(T cell large granular lymphocyte leukemia, T-LGLL)是具有细胞毒性的T淋巴细胞克隆性增殖所致的一种罕见淋巴增殖性疾病,以不同程度的血细胞减少和自身免疫性疾病发生为主要特点。以往研究提出,慢性抗原刺激与体细胞STAT3突变共同可导致白血病细胞的异常扩增,然而在本文之前,尚未有研究者系统地...
T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of mature, clonally expanded T cells, where somatic-activatingmutations are common. Although T-LGLL has been described as a chronic T cell response to an antigen, the function of the non-leukemic immune ...
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参考文献:Schreiber J, Pichler A, Kornauth C, et al. T-Cell Large Granular Lymphocyte Leukemia: An Interdisciplinary Issue? Front Oncol. 2022;12:805449. 本文来自流式中文网(flowcyto.cn)欢迎转发到朋友圈,但谢绝复制粘贴转载如有需要请联系mail@flowcyto.cn ...
T-cell large granular lymphocyte proliferation in myelodysplastic syndromes: Clinicopathological features and prognostic significanceZhangXiaohuiSokolLubomirBennettJohnM.MoscinskiLynnC.ingentaconnectLeukemia Research Oxford
．ｉｓｓｎ．１６７３ １４９２．２０１９．０６．０１２ 大颗粒淋巴细胞白血病（ｌａｒｇｅｇｒａｎｕｌａｒｌｙｍ ｐｈｏｃｙｔｉｃｌｅｕｋｅｍｉａ，ＬＧＬＬ）可分为Ｔ细胞来源（Ｔ ＬＧＬＬ）和ＮＫ细胞来源，后者根据病程可再 分为慢性ＮＫ细胞淋巴增殖性疾病（ＣＬＰＤ ＮＫ）和侵袭性ＮＫ细胞白血病［１］。...