Figure 7. PFS time versus T cell–inflamed GEP score in 244 patients fromKEYNOTE-012 and KEYNOTE-028 for the 9 cancer cohorts used to determine the T cell–inflamed GEP. TMB 与T cell–inflamed Gene expression profile 将肿瘤分成新的“四型”:A,TMB low,低免疫原性,TME中存在T细胞inflammed; ...
Ott PA, Bang Y, Razak ARA, Bennouna J, Soria J, Rugo HS, et al. Relation- ship of PD-L1 and a T-cell inflamed gene expression profile (GEP) to clinical response in a multicohort trial of solid tumors (KEYNOTE [KN028]). Ann Oncol. 2017;2(suppl_5):v22-42....
The introduction of anti-PD-1/PD-L1 therapies revolutionized treatment for advanced non-small cell lung cancer (NSCLC), yet response rates remain modest, underscoring the need for predictive biomarkers. While a T cell inflamed gene expression profile (GEP) has predicted anti-PD-1 response in ...
The SCLC-Y subtype was associated with high expression of interferon-γ response genes, highest weighted score on a validated 18-gene T-cell–inflamed gene expression profile score, and high expression of HLA and T-cell receptor genes. YAP1 protein expression was more prevalent and more ...
Results CX3CR1 previously expression reported a on memory CD8 þ T cells. We unique murine memory CD8 þ have T-cell population with proliferative potential that is distinct from TCM and is induced by non-professional antigen-presenting cells in the liver but not lymphoid tissues12. We ...
These tumors have been described as T cell-inflamed and demonstrate a transcriptional profile driven by type I interferons (IFNs) as well as expression of many IFN-γ linked im- munosuppressive mechanisms [3]. This is in contrast with non-T cell-inflamed tumors, which have low TIL count ...
Peripheral T-cell lymphoma is a rare but aggressive tumor. Due to its rarity, the disease has not been completely understood. In our review, we look at this lymphoma at the molecular level based on available literature. We highlight the mechanism behind the progression and resistance of this ...
针对the T cell–inflamed GEP 的研究发现,对于不同组织来源的肿瘤在基线时即存在Th1和细胞毒T细胞的适应性反应,表现为IFN-γ通路活化,细胞溶解,抗原递呈,T细胞迁移运输,以及为了维持T细胞稳态而存在的抑制作用。这些适应性反应能够通过18个基因的 T cell inflamed Gene expression profile score进行描述。
cancer types have been identified: the IFN-γ signature, the Expanded immune gene signature and the T-cell inflamed signature.22Interestingly, patients rendering TR TIL products exhibited significantly higher scores for the three mentioned signatures, in particular for the T-cell inflamed GEP (Fig....
(measured by the T cell-inflamed gene expression profile or GEP), and was predictive of response to anti-PD-1/PD-L1 therapy across 26 tumour types (Spearman R = 0.54, Pearson R = 0.57) outperforming the T cell-inflamed GEP score (Spearman R = 0.25, Pearson R = 0.34) and with a ...