Our aim was to report the case of a delayed reaction to suxamethonium and analyze specific T cell lines with regard to their specificity, phenotype and cytokine profile. Methods: We generated a drug-specific T cell line from a biopsy at the site of positive intradermal reactions and analyzed...
5,14,40 Nonetheless, delayed CRS occurring up to 3 weeks after CAR T-cell administration has also been reported.31,32,48 CRP and ferritin have been proposed as biomarkers for CRS prediction, as they correlate with the severity of CRS.3,7,33 However, CRP does not always precede CRS and ...
Allergic contact dermatitis is a delayed-type hypersensitivity reaction mediated by hapten-specific T cells (De Panfilis, 1998). During the sensitization phases, both CD4+ and CD8+ T-cell precursors are activated in the draining lymph nodes by presentation of haptenated peptides. Re-challenge with...
After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have gained a detailed knowledge of the cells involved, specific recognition mechanisms and post-recognition perforin–granzyme-based and FAS-based molecular mechanisms. What could not be anticipated at the outset was...
Besides, AR patients showed an increase in memory CD4 + T cells and a decrease in naïve CD4 + T cells, while AR + ACD patients showed similar changes in CD8 + T cell subsets. The allergic condition lead to the formation of a pool of memory allergen [19], while ...
Table 1 Characteristics of the study cohort – Multisensitzed allergic patients were subgrouped according to their reaction profile. Full size table Figure 2 CD4+T cell responses of allergic and non-allergic donors to common allergen sources. CFSE-labeled PBMCs of allergic and non-allergic individu...
5 Corticosteroids Cortico-steroids suppress T-cell function and/or induce T-cell apoptosis, and should be avoided for indications such as a pre-medication for blood products or for treatment of an allergic reaction. A steroid washout period is required prior to apheresis and CAR-T infusion;...
Rheumatoid arthritis (RA) is an organ-specific, but often also systemic autoimmune disease initiated and maintained by a chronic cell-mediated and humoral inflammatory response. T-cell response(s) to unknown antigen(s) are thought to be at the origin of
6.14 血细胞回收 cell salvage 术中将手术吸引装置中的血液和/或手术创口流出的血液回收,并进行洗涤等处理后回输的过程。 6.15 大量输血 massive transfusion 短时间内连续、快速输注大量血液。通常是指24h内输入的血液总量等于或超出患者全身血容量,...
44, 45 These data suggest that even if IL-10 can modulate allergic reactions, it may not be considered as an essential player for induction and maintenance of global tolerance against airborne antigens in humans. How does the technological approach for antigen-specific T-cell analysis impact on...