Invited Review: The Biology of the T Cell in the MouseKeywords immunityT cellmousehelper cellsuppressor cellkiller celldelayed type hypersensitivityAn abstract is unavailable. This article is available as a PDF only.doi:10.3109/00313028209092118Miller...
A relatively new paradigm in αβCD4 T-cell biology indicates that T cells are much more flexible than previously appreciated, with the ability to change between helper phenotypes, between helper and follicular helper, or, most extremely, between helper and regulatory functions. In this review, ...
Here we provide updates on our understanding of the longevity, functional heterogeneity, differentiation, plasticity, migration and human immunodeficiency virus reservoirs as well as key technological advances that are facilitating the characterization of memory CD4+ T cell biology. This is a preview of ...
In this Review, we describe the basic mechanisms used by TReg cells to mediate suppression and discuss whether one or many of these mechanisms are likely to be crucial for TReg-cell function. In addition, we propose the hypothesis that effector T cells may not be 'innocent' parties in this...
(for review see Jonuleit H, Schmitt E. The regulatory T cell family: distinct subsets and their interrelations. J Immunol 2003;171:6323–6327.) Briefly, T regulatory (Tr)-1 cells as well as T helper (Th)-3 T cells express common T cell markers such as CD4 and are characterized by ...
In this review, we summarize the application of CRISPR–Cas9 on T cell activation, differentiation, and function. First, we describe the CRISPR–Cas9 application on different T cells. We then discuss its application in the adoptive T cells therapies in preclinical and clinical research. Finally, ...
L. et al. Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review. Arthritis Res. Ther. 20, 229 (2018). Article PubMed PubMed Central CAS Google Scholar Horiuchi, T., Mitoma, H., Harashima, S., Tsukamoto, H. & Shimoda, T. ...
This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and rec...
Transcriptional regulation of the actin-bundling protein and tumor marker Fascin is highly diverse depending on cell and tumor type. Previously, we discovered that the viral oncoprotein Tax-1 of human T-cell leukemia virus type 1 (HTLV-1) considerably enhances Fascin expression in T-cells, dependi...
In this Review, we describe the thymic development of NKT cells, MAIT cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development. This is a preview of subscription content, access via your institution Access options Access Nature ...