T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive neoplasm of lymphoblasts committed to the T-cell lineage. In 1994, the WHO Classification of Hematologic Malignancies defined T-ALL as precursor T lymphoblastic leukemia/lymphoblastic lymphoma underscoring the unity between the two ...
On July 5, 2024, Prof. JIN Jie from the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZU) published an article entitled “Homoharringtonine Inhibits the NOTCH/MYC Pathway and Exhibits Anti-Tumor Effect...
2021年7月,北京高博博仁医院潘静主任团队、中国医学科学院血液病医院(中国医学科学院血液学研究所)冯晓明教授团队、同济大学医学院张鸿声教授团队等机构共同完成的“Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute...
急性T淋巴细胞白血病(T-cell acute lymphoblastic leukemia,T-ALL)为T系前体细胞恶性转化所致的一组异质性极强的血液系统恶性肿瘤,与B前体细胞急性淋巴细胞白血病(B cell precursor ALL,BCP-ALL)在临床特征、细胞遗传学、分子生物学及相关信号传导路径异常等方面具有显著差异。T-ALL在儿童和成人ALL中分别占10%~15%和...
为了攻克这个难题,中国人民解放军西部战区总医院血液科等单位的研究人员在《Heliyon》期刊上发表了一篇名为《Rapid development of acute monocytic leukemia (AML-M5b) with t (9;11)(p22;q23) after chemotherapy for T-cell lymphoblastic lymphoma: A case report》的论文。他们通过研究发现,T-LBL 进展为 AML...
早期前体T细胞急性淋巴细胞白血病(early T cell precursor acute lymphoblastic leukemia,ETP-ALL)是2016年WHO淋巴造血组织肿瘤分类提出的一种T细胞急性淋巴细胞白血病(T-ALL)建议分类亚型[1]。2009 年 Coustan-Smith 等首次提出部分T-ALL细胞起源于ETP细胞的假设,并通过免疫表型以及基因表达谱分析在儿童T-ALL中证实了...
时隔近两年,有关该项研究长期安全性和疗效持久性的2年随访结果,也已出炉:“Long-term follow-up of donor-derived CD7 CAR T-cell therapy in patients with T-cell acute lymphoblastic leukemia”并于近期发表于Journal of Hematology & Oncology(IF=23.168)(图2)。
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant neoplasm of the lymphocyte precursors that suffered malignant transformation arresting the lymphoid cell differentiation. Clinical studies revealed monoor, more rarely, oligoclonal nature of the disease. A precise identification of ...
T-cell acute lymphoblastic leukemia (T-ALL) is a curable malignancy in the pediatric population. However, population-level data on its incidence and outcomes among adults is sparse. Using SEER database, we identified 1141 patients aged ≥20 years with pathologically confirmed T-ALL diagnosed ...
Adolfo Ferrando and colleagues identify frequent inactivating mutations and deletions in the X chromosome gene PHF6 in T-cell acute lymphoblastic leukemia. PHF6 mutations are found almost exclusively in males and are associated with leukemias driven by a