The t BuOK-catalyzed intramolecular anionic cycloaddition of unsymmetrical bis-propargyl ethers has been applied to the synthesis of naphthofurans. A systematic study of the cyclization system revealed that the amount of base and solvent played an essential role in this reaction. The results showed ...
In the presence of potassium tert-butoxide (t-BuOK), the cross-coupling reaction between aryl fluorides and dimethyldisulfide was developed. A series of aryl methyl sulfides were obtained in moderate to good yields under transition-metal-free and mild conditions. Graphical abstract Abstract: The met...
本发明涉及取代的吡唑化合物、其药物组合物和使用方法,该取代的吡唑化合物为核受体rorγt的调节剂。更具体地,rorγt调节剂可用于预防、治疗或改善rorγt介导的炎性综合征、障碍或疾病。 [0006] 发明背景 [0007] 视黄酸相关的核受体γt(rorγt)是仅在免疫系统的细胞中表达的核受体,并且是驱动th17细胞分化的关...
然后加入t-buok(500mg,4.32mmol),室温下反应。反应结束后将反应液减压浓缩,浓缩液用dcm(20ml)稀释,依次用饱和na2co3溶液(35ml)和饱和nacl溶液(25ml)洗涤,无水na2so4干燥,过滤后减压浓缩,浓缩液经硅胶柱层析分离(淋洗剂:pe/etoac(v/v)=10/1),得到白色固体(780mg,97%)。ms(esi,pos.ion)m/z:458.9[m+h...
可以通过在t‑BuOH中与醇盐碱诸如t‑ BuOK一起加热来促进异构体混合物的平衡,以使混合物富含1RS,2RS,4RS异构体。该平衡的 混合物与CbzCl在NaHCO 水溶液中反应,然后用EtOAc/己烷研磨产物,可以得到(1RS,2RS, 3 4RS)‑I‑IV,为单一非对映异构体。使用手性固定相通过SFC拆分(1RS,2RS,4RS)‑I‑IV...
Buchwald 反应常用的钯催化剂为:Pd2(dba)3, Pd(OAc)2;常用碱有:Cs2CO3, t-BuOK,t-BuONa,常用溶剂: 甲苯,二甲苯,对碘代芳烃反应尤其突出;1,4-二氧六环,由于其自身毒性,有时会用Bu2O代替;叔丁醇也会被用到,如果反应需要更高温度,可用叔戊醇代替。
Reductive cyanation of 1,4-dioxaspiro[4.5]decaK-8-one (F-I) using TosMIC with an alkoxide base, such as t-BuOK, in a solvent mixture such as DME/t-BuOH can give cyanocyclohexane K-I. Reduction of K-I with LAH in an ethereal solvent can give amine K-II. Reaction of K-II with ...
Synthesis of Naphthofurans by tBuOK〤atalyzed Intramolecular Anionic Cycloaddition of Unsymmetrical Bis﹑ropargyl Ethersdoi:10.1002/ejoc.201500969Fused ring systemsCycloadditionEthersAlkynesTamíris B. GrimaldiDepartamento de Química Orgânica Laboratório de Síntese, Reatividade, Avaliação Farmacológica ...
Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic ChemistrySUNGGK,KYO HA.Enantioselective Michael addition cat-alyzed by chiral tripodal oxazoline-tBuOKcomplexes. Tetrahedron Letters . 2001...
Mechanism studies have shown that α-aminoalkyl radicals act as intermediates and hydrogen atom transfer (HAT) plays a crucial role in the tBuOK/DMSO/O2 system.doi:10.1039/d2qo01911fZhangqiang YanCollege of Chemistry and Chemical EngineeringZhen Zhang...