BIOLOGICALACTIVITY⽣物活性Tauro-β-muricholicAcidsodium(T-βMCAsodium)⼀种内性代谢物,⼀种竞争性、可逆的FXR拮抗剂,其IC50值为40μM[1][2][3]。IC50&TargetIC50:40μM(FXR)[1]体外研究T-βMCAsodiuminhibitsFXRreporteractivityintheCRCcelllineHT29(EC50~10μM)[3].T-βMCAsodiumdose-dependently...
J Smisterova,A Wagenaar,MCA Stuart,... - 《Journal of Biological Chemistry》 被引量: 267发表: 2001年 Nucleosome positioning by genomic excluding-energy barriers Recent genome-wide nucleosome mappings along with bioinformatics studies have confirmed that the DNA sequence plays a more important role...
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To address this hypothesis, we first demonstrated that gammadelta T cell-deficient mice had a significantly higher incidence of tumor development after challenge with a chemical carcinogen methylcholanthrene (MCA) or inoculation with the melanoma cell line B16. In wild-type mice, ga...
MCA-205细胞系;细胞传代方法:1:2-1:3传代;每周换液2-3次;细胞形态特性:详见细胞说明书;细胞生长特性:贴壁;细胞背景资料:纤维肉瘤 NT2-D1细胞系;细胞传代方法:1:2-1:3传代;每周换液2-3次;细胞形态特性:详见细胞说明书;细胞生长特性:贴壁或悬浮,详见细胞说明书部分;细胞背景资料:详见相关文献介绍 ...
(Fig.3g–j), whereas H121 colonization led to an increase in glyco-beta-muricholic acid (GβMCA) (Fig.3k). Female mice displayed the most significantTuricibacter-associated changes in circulating bile species, lipids, and cholesterol, indicating sex-dependent responses toTuricibactercolonization...
We sought to determine whether CD8+T cells upregulate Chop expression upon infiltration into the TME. ThusDdit3mRNA levels were assessed in CD8+T cells sorted from the spleens of tumor-free mice or tumors and spleens of mice bearing subcutaneous (s.c.) 3LL, EL-4, MCA-38, or B16 cance...
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one cell indicate clonal expansion following antigen encounter23,24and, therefore, identify antigen-experienced TC clones, overlapping TCR sequences between Treg and Tconv indicate conversion of antigen-experienced Tconv into secondary iTreg. Using TCR sequencing a recent study in the MCA (3-methyl...
MCA 38Cells;细胞背景资料:详见相关文献介绍;细胞传代方法:1:2传代;细胞生长特性:贴壁生长;细胞形态特性:上皮细胞样;相关细胞有:Plaepi 34Cells、LAPC-4Cells、C3A细胞 HCMECCells;细胞背景资料:心脏微血管;内皮Cells;细胞传代方法:1:2-1:3传代;每周换液2-3次。;细胞生长特性:贴壁;细胞形态特性:详见细胞说明...