图1. a. 描述NOTCH1诱导的T - ALL小鼠模型的生成和PD-1-和PD-1+ T-ALL细胞白血病启动能力的定量示意图;b. PD-1-和PD-1+ T-ALL细胞移植后6周的代表性FACS图(n= 5只小鼠) 为了评估PD-1在T - ALL中的作用,该研究使用...
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty acid β-oxidation (FAO). PD-1 promotes FAO...
anti-PD-1 treatment (NCT02631746(refs.5,6),NCT03075553(ref.7)). While all these clinical observations highlight the critical importance of inhibitory PD-1 signaling in T cell malignancies, the tumor-suppressive mechanisms of PD-1 remain unknown. In non-transformed T cells, acute PD-1 engagem...
所有受试者均患有晚期肝细胞癌,并且经过化疗、TACE(肝动脉化疗栓塞术)和靶向治疗均无效。9例可评估受试者中,4例达到部分缓解 (PR),3例达到疾病稳定 (SD),2例出现疾病进展 (PD),客观缓解率为44%,疾病控制率达到78%。 相关文章: ...
为了避免CAR-T细胞的自相残杀，Beam通过碱基编辑，敲除CAR-T细胞表面的CD7。同时敲除TRAC（T细胞受体α恒定区），清除T细胞表面受体，避免移植物抗宿主病（GvHD），敲除CD52，避免患者对CAR-T细胞的排异反应，还敲除了PD-1，提高CAR-T细胞抗肿瘤活性的持久性。从而成功构建了7CAR8。实验结果显示，平均92.9%的T细胞...
This study provided biological evidence that HnRNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. Graphical abstract Inhibition of HnRNP L diminishes PD-L1 expression and promotes antitumor immunity via destabilizing ...
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Programmed cell death-1 (PD-1) is another immune checkpoint molecule that restrains T cell response (Freeman et al., 2000), which can cause exhaustion of effector T cells during chronic infections and cancer immune evasion (Crawford et al., 2014; Wherry, 2011; Wherry et al., 2007). It...
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