Jurkat transduced with a CAR-targeting antigen, which was expressed on other cancer cells, could kill other cancer cell lines, demonstrating that T-ALL cells could be used as tool cells for cancer therapy. Our study supplied a new feasible treatment regimen for cancer treatment in the ...
Significant advances have been made in chimeric antigen receptor T (CAR-T)-cell therapy for the treatment of recurrent or refractory B-cell hematologic malignancies. However, CAR-T-cell therapy has not yet achieved comparable success in the management of
CAR-NK与CAR-T相比,NK细胞通过另外两个共刺激分子,即NKG2D和CD244(2B4)增加其细胞毒性能力和细胞因子的产生。因此,比CAR-T细胞具有更强的肿瘤特异性靶向性和细胞毒性。CAR-NK细胞疗法可能在未来成为CAR-T疗法的替代方案,因为CAR-NK细胞具有以下超越CAR-T的几...
1.The Past, Present, and Future of Non-Viral CAR T Cells. Front Immunol.2022; 13: 867013.
In recent decades, the advent of immune-based therapies, most notably Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment. The promising results of numerous studies indicate that CAR-T cell therapy has had a remarkable abil
CMS has proposed a different way to handle payment for chimeric antigen receptor T-cell therapy, one that the medical and manufacturing community thinks is unworkable.
This review focuses on selected literature on CAR T-cell therapy for CLL, including the interim results of key ongoing studies, with an emphasis on recent research. 展开 关键词: B-cell lymphoma CART cells cell therapy CLL FOLLOW-UP MALIGNANCIES OBINUTUZUMAB MULTICENTER REMISSIONS VENETOCLAX LYMPHOMAS...
Chimeric antigen receptor (CAR) T cell therapies have evolved from a research tool to a concept-shifting therapy with impressive responses in B cell malignancies. This Review summarizes the current state of the CAR T cell field, focusing on CD19- and B cell maturation antigen-directed CAR T ...
Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer treatment. Although treatment with CAR-T cells has produced remarkable clinical responses with certain subsets of B cell leukemia or lymphoma, many challenges limit th
Adoptive cell therapy with chimeric antigen receptor (CAR) immunotherapy has made tremendous progress with five CAR T therapies approved by the US Food and Drug Administration for hematological malignancies. However, CAR immunotherapy in solid tumors lags significantly behind. Some of the major hurdles ...