*** Systemic sclerosis (SSc), also known as scleroderma, is a progressive, chronic, and debilitating auto-immune disease; the cause is unknown. Some patients have a mild form of disease, including few symptoms and a mild course; others have a severe form...
Systemic sclerosis is more common in women. It can be mild or severe. Common symptoms include Raynaud’s syndrome, polyarthralgia, dysphagia, heartburn, and swelling and eventually skin tightening and contractures of the fingers. Lung, heart, and kidney involvement accounts for most deaths. ...
Systemic Sclerosis(SSc) /Scleroderma ● Symptoms and Causes Scleroderma is an autoimmune disease of the connective tissue caused by increased production and accumulation of the protein collagen in the body tissues. Collagen overproduction could be influenced by: Abnormal immune reactions/Changes in genes...
12.There are dozens of symptoms of Systemic Sclerosis, and a huge variance in how people are affected by it.系统性硬皮病有许多种症状,在不同的人身上表现则有所不同。 13.The Clinical Study on Tuberous Sclerosis Complex and Mutational Analysis of TSC2 in Cases of a Pedigree;结节性硬化症的临床...
Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by widespread fibrosis affecting the skin, internal organs, and vasculature. Yet, most available therapies for SSc are organ-specific, such as proton pump inhibitors for gastroesophageal reflux; angiotensin converting enzyme inhibitors...
Thoua, N. M. et al. Assessment of gastrointestinal symptoms in patients with systemic sclerosis in a UK tertiary referral centre.Rheumatology49, 1770–1775 (2010). ArticlePubMedGoogle Scholar Fretheim, H. et al. Multidimensional tracking of phenotypes and organ involvement in a complete nationwide...
The assessment of disease activity in systemic sclerosis (SSc) is challenging owing to its heterogeneous manifestations across multiple organ systems, the variable rate of disease progression and regression, and the relative paucity of patients in early-phase therapeutic trials. Despite some recent succes...
Systemic sclerosis (SSc) is considered by many to be one of the most severe autoimmune rheumatic diseases with lower prevalence observed in Northern Europe. No previous studies on the prevalence of SSc in Latvia have been conducted and the aim was to study the demographic and clinical data of ...
et al. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J. Clin. Invest. 125, 2795–2807 (2015). PubMed PubMed Central Google Scholar US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01371305 (...
BACKGROUND: Symptoms associated with small intestinal involvement in patients with systemic sclerosis (SSc) are usually severe and resistant to treatment. OBJECTIVES: To assess the safety and efficacy of octreotide in refractory small intestinal disease complicating SSc. METHODS: Seven female patients (...