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Ongoing advances in the field of microfabrication have provided an opportunity to encourage regulatory drug delivery systems. In this regard, we will address two types of transport gadgets: microreservoir and small / nanofluidic gadgets. For each type of transmission gadget, we start with the ...
et al. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr. Biol. 5, 1119–1129 (2013). Article CAS Google Scholar Nieskens, T. T. G., Persson, M., Kelly, E. J. & Sjögren, A.-K. A multicompartment human kidney proximal tubule-on-a-...
et al. Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming. Cell 176, 928–943 (2019). Article PubMed PubMed Central Google Scholar Ebrahimi, A. et al. Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming....
the drug’s bioactivity. ELPs may be precisely controlled in terms of shape and chemistry to obtain drug binding sites, as they are genetically encoded and recombinantly expressed. Accordingly, ELPs are widely used in the field of designing targeted biomolecules and in drug transport [74,103]....
The cardiovascular system (CVS) is made up of the heart, blood vessels, and blood. The fundamental function of CVS is to transport substances to and from all parts of the body. The heart is the major pumping organ, pressurizing blood for circulation thro
However, they do require energy for various functions, including maintenance of shape and deformability, active transport, and prevention of oxidative damage. Red blood cells generate this energy entirely through glycolysis (also known as the Embden-Meyerhof pathway). Except in pigs, glucose enters ...
skin properties allow the transport of a limited number of agents through passivetransdermaldelivery; for example, small lipophilic APIs, when dosage and consistency of release are not critical, are poised for transcutaneous delivery. Achieving sufficient drug absorption can prove to be a challenge for...
could be used to investigate the peripheral vs. CNS action of drug molecules such as opioids. To limit BBB penetration, a drug molecule is typically modified to increase its size and hydrophilicity. However, this often adversely affects the potency and pharmacokinetic properties of the drug ...
(green arrow); The decomposition process of GSH, GSSG and GS-X after being squeezed out of cells (purple arrows); The decomposition process of intracellular GSH (rosy arrows); ROS are generated from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX)...