Worldwide, syphilis is far from eradicated, especially in resource-limited areas, and it can affect any part of the neuraxis at any stage of infection [10, 15, 37]. There is a growing consensus that neurosyphilis patients can benefit from prompt standardized treatment [38]. The current stud...
Syphilis, which is caused by the sexually transmitted bacteriumTreponema pallidumsubsp.pallidum, has an estimated 6.3 million cases worldwide per annum. In the past ten years, the incidence of syphilis has increased by more than 150% in some high-income countries, but the evolution and epidemiolog...
Globally, the World Health Organization (WHO) has estimated that 7 in 1000 pregnant women have a maternal syphilis infection. This has caused over 200,000 annual neonatal deaths and 1.5 million cases of infected newborns reported worldwide in 2023, with almost two-thirds of all cases being foun...
World Health Organization References UNAIDS epidemiological estimates, 2021. Available at https://www.unaids.org/en/resources/documents/2021/2021_unaids_data. Accessed 15 Jul 2022. Mid-year population estimates 2021. Republic of South Africa: statistics South Africa; 2021. Statistical release P0302....
(3) avert the multitude of serious sequelae associated with syphilis, including neurosyphilis and ocular syphilis. This subunit vaccine candidate, inducing sterile protection againstT. palliduminfection, may offer a timely solution to the increasing threat of syphilis that is being observed worldwide. ...
Since its first description by Harn in 1943, the true prevalence of syphilitic hepatitis (SH) worldwide has remained unknown due to its unspecific and unremarkable clinical manifestations that can easily emulate other diseases [2]. Less than 10% of patients with primary and secondary syphilis can...
Each year, there are several million new infections reported worldwide [4]. In high-income countries, syphilis occurs at low rates in the general population, and a higher prevalence is only observed in specific populations (MSM, high-frequency sexual contact, and sex workers). In low-income ...
Syphilis and other sexually transmitted infections (STIs) are silent epidemics that affect high- and low-income countries worldwide. Although it is a treatable and preventable disease, according to data from the Center for Disease Control and Prevention (CDC), primary and secondary syphilis cases ...
It affects the health and lives of people worldwide and impacts reproductive and child health. Syphilis may also cause consequences during pregnancy, such as abortions, stillbirth, premature birth, infant or neonatal death, and early or late congenital manifestations [2]. The increased number of ...