His syphilis serology results are as follows: Syphilis EIA positive, RPR negative, TP-PA positive. How should these results be interpreted? We frequently encounter questions about the interpretation of syphilis serology and about the appropriate treatment of various clinical stages of syphilis. Data th...
Interpretation of serological tests for syphilis requires expertise to distinguish true infection from false-reactive tests. Once confirmed, treatment usually requires long-acting parenteral preparations of penicillin, followed by prolonged follow-up. For this reason, patients found to have positive syphilis...
3. Results Of 291 parent–infant pairs with syphilis detected during the pregnancy, we included 121 pregnant persons with 569 reactive RPR measurements (median 5, range 2 to 11 per person). The remaining pregnant persons did not have a documented fourfold decrease in RPR or had a fourfold ris...
Diseases which produce acute bio- • rat bite feverTEST RESULTS INTERPRETATIONRPR FTA-ABS (DS)Reactive or weakly reactive Reactive These results usually indicate syphillis.Tests should always be repeated on anew specimen if doubt exists.Nonreactive In absence of historical or clinicalevidence of ...
Diagnose using a nontreponemal (reaginic) test (eg, rapid plasma reagin [RPR] or Venereal Disease Research Laboratory [VDRL]), and confirm positive results using a treponemal antibody test. Treat with benzathine penicillin (Bicillin L-A) whenever possible, except that ocular syphilis, otic syphil...
Diseases which produce acute bio- • rat bite feverTEST RESULTS INTERPRETATIONRPR FTA-ABS (DS)Reactive or weakly reactive Reactive These results usually indicate syphillis.Tests should always be repeated on anew specimen if doubt exists.Nonreactive In absence of historical or clinicalevidence of ...
Trending Skin Lesions, Foot Drop, and Hand Contractures Case Report June 30, 2023 Screening for Genital Herpes Infection Opinion December 20, 2016This Issue Views 6,170 Citations 5 2 JAMA Diagnostic Test Interpretation November 12, 2014 RPR and the Serologic Diagnosis of Syphilis Meredith...
and false-positive results do not occur in experienced hands.Serologic testscan be useful in the diagnosis of primary syphilis, although false-negative results occur 10–20% of the time. The rapid plasmareagin(RPR) and the Venereal Diseases Research Laboratory (VDRL) are referred to as ‘nontre...
Dunseth et al. underlined the necessity of differentiation between analytical false-positive results of lues tests from clinical false-positive results. A positive syphilis IgG screen with negative RPR and T. pallidum particle agglutination assay (TP-PA) confirmatory testing could be considered an analy...
Because of the false-positive test results with initial treponemal testing (ie, CIA or EIA) and a negative RPR and TPPA result in low-risk patients or low-prevalence populations, clinician education on the reverse sequencing algorithm and interpretation and limitations of syphilis serologic test ...