Synthetic Design: An Optimization Approach to Experimental Design with Synthetic ControlsNick DoudchenkoKhashayar KhosraviJean Pouget AbadieGuido Imbens
This repository is for reproducing the main experimental results in the AISTATS'24 paper: "Adaptive experiment design with synthetic controls". The method proposed in the paper, Syntax, is implemented as a combination of infer_synthetic and recruit_adaptive in src/algs.py....
A transition-metal-free platform enables the formation of challenging C(sp3)–C(sp3) bonds in organic compounds via single-electron transfer, facilitating the coupling of functionalized fragments and expanding possibilities for efficient organic synthesis and reaction design. Sven Roediger , Emilien Le ...
Research has shown that the synthetic jet behavior is dependent on the diaphragm and the cavity design hence, the focus of this work. The performance of the synthetic jet is studied under various factors related to the diaphragm and the cavity geometry. Four diaphragms, manufactured from ...
Overall, we found higher model accuracy when the in vivo dataset’s experimental design yielded more precise transcription rate measurements. For example, Urtecho et al. integrated all test genetic circuits into the E. coli genome to reduce the variation in DNA copy number. They also utilized ...
For example, the interaction effect of pre-test and treatment is a function of the four quantities. The quantity in experimental group 1 isQE1=f(α+δ+γ+τ+I). The quantity in experimental group 2 isQE2=f(α+γ+δ). The quantity in control group 1 isQC1=f(α+τ+γ), and the...
1 shows that the spectra for all the pL polyproteins have the same profile as the pL monomer, demonstrating that the pL polyproteins are in a folded conformation, thus allowing us to control the aspect ratio by controlling the number of tandem repeats. Fig. 1: Aspect ratio controls the ...
Continued application of Cas12a for CRISPR screening will enable the experimental identification of higher-order combinatorial GIs in human cells. However, for pairwise interactions of paralogs, the pgPEN library may provide an ease of application to investigators with Cas9-expressing cell systems ...
5), thus confirming the specificity of the synthetic lethal interactions predicted by SLIdR. Taken together, our experimental data strongly support the two HCC SL pairs predicted by SLIdR. Integration with CRISPR data We applied SLIdR to CRISPR data from the DepMap consortium (Project Achilles)57 ...
so, facilitate the correct assembly of multi-subunit complexes (i.g. cytochromes, catalases, P450 enzymes, and carboxysomes).In particular, improvements in synthetic biology have made possible to study gene regulatory networks (GRNs) in a simplified setting amenable for exact experimental controls....