Synthetic biologyReductionismMetaphysicsScientific research practicesThe life sciences have evoked long-standing philosophical debates on a system view of life versus a reductionist view that reduces the complexity of life-forms to parts-based entities that can be described purely mechanistically. This paper...
This paper proposes a new methodology for the automated design of cell models for systems and synthetic biology. Our modelling framework is based on P syst
The triterpene oil squalene is an essential component of nanoemulsion vaccine adjuvants. It is most notably in the MF59 adjuvant, a component in some seasonal influenza vaccines, in stockpiled, emulsion-based adjuvanted pandemic influenza vaccines, and w
The development of the CRISPR-Cas system has been revolutionary within the field of gene therapy by empowering direct and specific genome editing. This is achieved through using guide RNA (gRNA) to direct introduction of a double-stranded break in DNA65. To date, synthetic biology has been appl...
Studies of the regenerating hematopoietic system have led to the definition of many of the fundamental principles of stem cell biology. Therapies based on a range of tissue stem cells have been widely touted as a new treatment modality, ... GQ Daley,MA Goodell,EY Snyder - 《Hematology Am Soc...
The Synthetic Biology Revolution Investing in the Science of Sustainability The revolutionary technology of synthetic biology is poised to make a profound impact on the way a vast array of products are manufactured, from lab-grown meat to cosmetics to biodegradable packaging. Yet investors are still ...
The Central Dogma of molecular biology DNA is the most upstream source of biological information. It harbors the genes, which are the "blueprints" for making functional biological entities. Unique- ly, DNA has the gift of self-renewal, as it gets replicated during cell division. The non...
A second pgPEN screen identifies shared versus cell-line-specific paralog synthetic lethal interactions Next, we applied the pgPEN approach to a different tissue context, HeLa cervical carcinoma cells, using similar methodology, with the exception of using a doxycycline-inducible Cas9 system (Cao et...
For centuries, biology was centred on the analysis of the microscopic and macroscopic worlds, but since the end of the 19th century it progressively adopted synthesis as a means to understand biological systems, strengthened recently by the dawn of synth
hyperosmolality by exploiting osmotic response elements (OREs) for the expression of unstable blue fluorescent protein (BFP, FKBP-BFP), enabling the simultaneous automated supervision of two bioprocess parameters by using a dual sensor CHO cell line transfected with a multiplexable monitoring system. We...