natural productssynthetic biologyThe diversity and natural modularity of their biosynthetic pathways has turned natural products into attractive, but challenging, targets for synthetic biology approaches. Here, we discuss the current state of the field, highlighting recent advances and remaining bottlenecks....
My research interests mainly focus on activation of silent fungal biosynthetic gene cluster and synthetic biological reconstruction of bioactive pharmaceuticals. Research More > The objectives of my research are: (a) to discover novel fungal natural product according to the epigenetic regulation or ...
Biology has been limited by “poke and measure the response” research strategies. Recombinant DNA technology allowed biologists to take the next step through synthesis of different sequences of natural molecules. But synthetic biology with 'bottom-up' design may achieve much more. Building artificial...
This review discusses advances in recent years that can accelerate the design, build, test, and learn (DBTL) cycle of natural product discovery, and prospects trends and key challenges for future research directions. Keywords: natural products; biosynthetic gene clusters; synthetic biology; genome ...
is a natural product. All natural products have onefeatureincommon,biosynthesesbyageneticallyencodedpathway,and the possibilities for re-engineering these pathways connectsnatural products to synthetic biology.The opening quotation’s classif i cation would dif f erentiatenatural products into the known ...
SummarySynthetic Biology is in a critical phase of its development: it has finally reached the point where it can move from proof-of-principle studies to real-world applications. Secondary metabolite biosynthesis, especially the discovery and production of antibiotics, is a particularly relevant target...
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragr
Synthetic biology is the design and construction of new biological parts, devices, and systems, and the re-design of existing, natural biological systems for useful purposes. Featured Hashing the message with cells The programming of multicellular processes for biological computation requires increasingly...
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragr
Pharmaceuticals have inspired some of the earliest success stories of synthetic biology for two main reasons: on the one hand, small-molecule drugs in current use (from aspirin to artemisinin) are very often derived from natural products, so that a return to microbial production systems is seen ...