Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragr
The Synthetic Biology Revolution Investing in the Science of Sustainability The revolutionary technology of synthetic biology is poised to make a profound impact on the way a vast array of products are manufactured, from lab-grown meat to cosmetics to biodegradable packaging. Yet investors are still ...
Vector-borne diseases in humans occur through snails, mosquitoes, fleas, ticks, lice, sandflies, and tsetse flies infected with microbes. These comprise over 17% of all infectious diseases and significantly contribute to the burden of disease and economy. Mosquito-borne diseases account for nearly ...
The versatility of RNA in sensing and interacting with small molecules, proteins and other nucleic acids while encoding genetic instructions for protein translation makes it a powerful substrate for engineering biological systems. RNA devices integrate c
The complexity of microbial communities, combined with technical biases in next-generation sequencing, pose a challenge to metagenomic analysis. Here, we develop a set of internal DNA standards, termed “sequins” (sequencing spike-ins), that together co
Finally, we comment on the experimental realization of our strain using a synthetic biology approach. One underlying assumption for constraint-based flux balance analysis is to use biomass as an objective and maximize the growth rate. Such flux balance analysis identifies key enzymes for such metaboli...
We designed a novel hybrid synthesis of a naturally occurring SGL, generated CD1b tetramers loaded with natural or synthetic SGL analogs, and studied the molecular requirements for TCR binding and T cell activation. Two T cell lines derived using natural SGLs are activated by synthetic analogs ...
Objective: In this work, in order to optimize the structure of histidine-containing antifungal peptides with a "linear" type of amphipathicity (LTA), we carried out the synthesis and comparative screening of the antifungal activity of a series of histidine-containing SAMPs ( F2H7 , F2H10 , ...
4,5, Felix Getzke1,5, Guillaume Chesneau1, Laura Dethier1, Jana Ordon 1, Thorsten Thiergart1 & Stéphane Hacquard 1,2 The identification of processes activated by specific microbes during micro- biota colonization of plant roots has been hampered by technical constraints in metatranscriptomics....
The versatility of RNA in sensing and interacting with small molecules, proteins and other nucleic acids while encoding genetic instructions for protein translation makes it a powerful substrate for engineering biological systems. RNA devices integrate c