PAF-mediated synthesis of prostaglandins was inhibited by the Ca2+ ion chelator (EGTA), the Ca2+ channel antagonist (nifedipine) and U66985, a structural analogue and antagonist of the biological effects of PAF in other cellular systems. Inhibitors of protein kinase C, staurosporine and polymixin ...
Ischemia, trauma and hormonal stimulation elicit the release of prostaglandins (PGs) from the heart. Although PGI 2 is synthesized by coronary arteries, the capacities for PG synthesis of individual types of cells comprising the heart have not been elucidated. Accordingly, synthesis of prostaglandins ...
Normal palatal growth is regulated in part by hormones and growth factors. Because hormonal responsiveness of some cells correlates with their cell density, we have investigated the relationship between embryonic palate mesenchymal cell population density and their ability to synthesize prostaglandins (PGs)...
Prostaglandins (PGs) have been implicated in the development of pulmonary oxygen toxicity. We tested the hypothesis that hyperoxia modulates PG synthesis in a differentiation-arrested primary lung cell culture model in the rat at three developmental ages: day-20 gestation (term = 22 days), days 1...
The addition of prostaglandins E2 (PGE2), PGD2, PGI2, 6-keto PGF1 alpha and thromboxane B2 (TXB2) to human monocyte cultures, inhibited the production of the second component of complement (C2). PGF2 alpha did not significantly affect C2 production. As the former compounds, but not the lat...
of the vasodilatory action of prostaglandins is found in thekidneys, in which widespread vasodilation leads to an increase in the flow of blood to the kidneys and an increase in the excretion ofsodiumin the urine. Thromboxanes, on the other hand, are powerful vasoconstrictors that cause a ...
Aspirin is an inhibitor of cyclooxygenase, which initiates the synthesis of prostaglandins and thromboxanes (Chapter 16). Aspirin therapy is beneficial in the prevention of heart attacks and strokes because it interferes with the function of platelets. However, aspirin may increase the risk of ...
It is not clear which is the most import... J C.,HAWKEY - 《Alimentary Pharmacology & Therapeutics》 被引量: 49发表: 1988年 Inhibition of prostanoid synthesis by anti-inflammatory drugs in human gastric mucosa The human gastric mucosa can produce several types of Prostaglandins (PGs) and ...
Sugar esters display surface-active properties, wetting, emulsifying, and other physicochemical phenomena following their amphipathic nature and recognize distinct biological activity. The development of nutritional pharmaceuticals and other applications
Prostaglandins are synthesised from arachadonic acid by COX-1 and COX-2. Arachadonic acid is in turn derived from the cell membrane phospholipid bilayer by the activity of phospholipase enzymes in response to trauma, cytokines and growth factors (Funk, 2001). Prostaglandins act in an autocrine ...