(R)-(-)-5-Hydroxymethyl-2-pyrrolidinone C060 4-Boc-piperazine-2-(R)-carboxylic acid C064 2-(R)-Piperazine carboxylic acid 2HCl C126 R-(-)-1-Indanol C199 Benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate hydrochloride C257 ...
Synthesis of chiral N-aryl pyrrolidinones via a palladium-catalyzed cross-coupling reaction Synthesis of chiral N-aryl pyrrolidinones via a palladium-catalyzed cross-coupling reactionpyrrole derivativesamination, N-alkylation, N-arylation... RG Browning,H Mahmud,V Badarinarayana,... - 《Cheminform》...
ChemInform Abstract: Stereoselective Alkylation of N‐Boc‐2‐pyrrolidinones and N‐Boc‐2‐piperidinones. Synthesis and Characterization of Disubstituted Lactams.stereochemistry (general, optical resolution)alkylation, arylation, dealkylation, dearylation, C‐acylation, olefination...
(R)-1-BOC-3-pyrrolidinol,CAS#103057-44-9 (R)-3-pyrrolidinol,CAS#2799-21-5 N-BOC-3-pyrrolidinone,CAS#101385-93-7 N-Methylcyclopentylamine,CAS#2439-56-7 O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine,CAS#6723-30-4 2-(2-Bromoethyl)-1,3-dioxalane,CAS#18742-02-4 2-OXO-4-BOC-1-pipe...
- 《Journal of Organic Chemistry》 被引量: 181发表: 1998年 Stereoselective alkylation of N-Boc-protected-5-substituted delta-lactams: synthesis of alpha, delta-disubstituted delta-amino acids N--protected-5-substituted delta-were readily prepared from the corresponding beta 3-amino acids. Alkylation...
In the pyrrolidinone series, 1,3-induction seems to be ruled by steric interactions and the diastereoselection is low for the alkylation of enolates with small substituents at C-5 (e.g., Me) and methyl iodide. The trans selectivity improves with bulkier substituents at C-2 and/or bulkier ...
This section will outline some of the most relevant routes reported. 2.1. Königs-Knorr reaction The attachment of sugar moieties onto polymerizable functions via Königs-Knorr reactions has been reported as early as the late-60′ with the attachment of N-carboxyanhydride (NCA) rings on various...
78% yield as a single diastereoisomer. Removal of theO-MOM andN-Boc groups and subsequent cyclization proceeded smoothly by simply stirring a dichloromethane solution of43in the presence of trifluoroacetic acid (TFA) to afford, after work-up with aqueous NaHCO3solution, the (-)-sinoracutine (...
4.6.2. Methyl N-Boc-3′-bromo-3H-spiro[isobenzofuran-1,4′-piperidine]-3-ylacetate (11) A 200-mL three-necked flask equipped with a three-way valve was charged with (R)-10 (1.80 g, 4.98 mmol) and CH3CN (50 mL). The clear solution was cooled to 0 °C, and NBS ...
We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle. A key breakthrough is the removal of a volatile Fmoc deprotection base through bulk evapor