The microwave-assisted synthesis of N-alkylbenzamides from benzoic acid and primary aliphatic amines has been developed under solvent-free conditions. The different solid catalysts have been investigated. The suggested synthesis is environmentally friendly and excellent yields (97 - 99 %) have been ...
Based on the structure-activity relationship in a variety of substituted benzamide derivatives that exhibit high affinity for CNS dopamine D2/D3 subreceptors, new benzamide derivatives labeled with -99have been designed. In this presentation, a new neutral ()complex, derived from benzamide by ...
Ten novel anthranilic diamides compounds containing fluorine and benzothiazole compounds were sythesized after benzoic acid containing fluorine unite chloridized by thionyl then coupled with 2-aminobenzoic acid,and cyclized in the existence of acetic anhydride,then coupled with substituted benzo[d]thiazol-...
Molecular modelling studies suggested the ability of compounds9mand9oto establish interactions with three hydrogen bonds to Asp267 and Glu346 of NHE-1, but also the ability with much lower CDOCKER energies than positive control cariporide and buthutin A. The structure鈥揳ctivity relationship (SAR...
Synthesis, spectral and quantum mechanical studies and molecular docking studies of Schiff base (E)2-hydroxy-5-(((4-(N-pyrimidin-2-yl)sulfamoyl)phenyl)imino)methyl benzoic acid from 5-formyl salicylic acid and sulfadiazine J. Indian Chem. Soc., 98 (2021), Article 100144, 10.1016/j.jics.20...
Aryl selenoamides are rather interesting compounds because they are versatile intermediates in organic chemistry1. It was reported that selenobenzamides have been used as selenium transfer reagents in the synthesis of alkyl diselenides from reactive hal关键词: Diacyl selenides selenium transfer reaction ...
The chemical synthesis of the TFMO containing amides started by coupling the commercially available 3- or 4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid (1 or 2) with benzylamine in the presence of equivalent amount of 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b...
et al. A convenient synthesis of N-aryl benzamides by rhodium-catalyzed ortho-amidation and decarboxylation of benzoic acids. Chem. Eur. J. 20, 1–5 (2014). Google Scholar Shi, X.-Y. et al. Ru(ii)-catalyzed ortho-amidation and decarboxylation of aromatic acids: a versatile route to ...
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of a library of novel benzamidobenzoic acid derivatives demonstrating potent KDM4B inhibitory activity and phenotypic immunosuppression. We further used this strategy to optimize a number of lead compounds demonstrating therapeutic potential for the treatment of periodontal disease based on suppression of ...