Aminoacyl-tRNAs have important roles in a variety of biological processes. Here, we describe the synthesis of stable aminoacyl-tRNA analogs containing 1,4-substituted 1,2,3-triazole rings. The procedure involves (i) copper-catalyzed cycloadditions of 3'-or 2'-azido-adenosine and alkynes, (ii)...
Intrinsic precision of aminoacyl-tRNA synthesis enhanced through parallel systems of ligands. Nature New Biol. 239, 106± 108.Yarus, M. 1972. Intrinsic precision of aminoacyl-tRNA synthe- sis enhanced through parallel systems of ligands. Nature New Biol. 239:106-108....
The accuracy of aminoacyl-tRNA synthesis is enhanced by a number of further protein-RNA or protein-protein interactions, some of which are restricted to Archaea, and might reflect adaptation mechanisms to diverse conditions.关键词: RNA, Transfer, Amino Acyl Amino Acyl-tRNA Synthetases Molecular ...
The activity of the enzyme, however, was identified recently, and it allowed the purification of the enzyme and cloning of its gene. Sequence analysis of the gene showed that it encodes proline-tRNA synthetase and, thus, raised the possibility of dual activities in a single aminoacyl-tRNA ...
The effects of a partial restriction of valyl-tRNA aminoacylation on the synthesis of aminoacyl-tRNA synthetases, ribosomal proteins, and other translation and transcription proteins were examined in otherwise isogenic stringent (relA+) and relaxed (relA1) derivatives of E. coli B. The synthesis of...
et al. Combining aldolases and transaminases for the synthesis of 2-amino-4-hydroxybutanoic acid. ACS Catal. 7, 1707–1711 (2017). Article CAS Google Scholar Vargas-Rodriguez, O., Sevostyanova, A., Söll, D. & Crnković, A. Upgrading aminoacyl-tRNA synthetases for genetic code ...
Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases 喜欢 0 阅读量: 25 作者: Xiang,Y.,Yu,and,Jason,M.,Hill,and,Guixue,Yu,and,Weiheng,Wang,and,Arthur,F.,Kluge,and,Phil,Wendler,and,Paul,Gallant 展开 摘要: A series of...
专利名称：tRNA SYNTHESIS METHOD, NUCLEIC ACID, AMINOACYL tRNA SYNTHESIS METHOD,AND PROCESS FOR PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN 发明人：YOKOYAMA, Shigeyuki, c/o RIKEN Yokohama Institute,SAKAMOTO, Kensaku,c/o RIKEN Yokohama Institute,YANAGISAWA, Tatsuo, c/o RIKEN ...
Yadavalli SS, Ibba M (2012) Quality control in aminoacyl-tRNA synthesis: Its role in translational fidelity. Adv Protein Chem Struct Biol 86: 1-43.Yadavalli, S. S. & Ibba, M. Quality control in aminoacyl-tRNA synthesis: its role in translational fidelity. Adv. Protein Chem. Struct. ...
Structural analysis has shown that yeast eEF3 HEAT (13) repeats interact with rRNA and the ribosomal proteins of the small ribosomal subunit, and this is proposed to play a role in the translocation of aminoacyl-tRNA from the A site to the P site on the ribosome123,124,125. Similarly, ...