2,4,5-Trisubstituted oxazoles were synthesized in good yields starting from α-methylene ketones by nitrosation, condensation with aldehydes and reduction with zinc in acetic acid at 40 °C. (5-Methyl-2-phenyloxazol-4-yl)ethanol was prepared by reduction of ethyl (5-methyl-2-phenyloxazol-4-...
One-pot synthesis of 2,4,5-trisubstituted oxazoles from N -acyl amino acids by a combination of cyclodehydration with N , N ′-diisopropylcarbodiimide and Wittig olefination[J] . Wenhua Huang,Guangping Dong,Zumureti Mijiti.Tetrahedron . 2011 (4)...
An efficient one-pot reaction of acid chlorides, terminal acetylenes, sodium azide and aryl halides is developed for the regioselective synthesis of 2,4,5-trisubstituted 1,2,3-triazoles. The method is general, convenient, eco-friendly, a... X Liu,J Li,B Chen - 《New Journal of Chemistry...
Synthesis of 2,4,5-Trisubstituted Oxazoles with Complementary Regioselectivity from α-Oxoketene Dithioacetals and β-(Methylthio)-β-(het)aryl-2-propenones. An efficient protocol for the synthesis of 2,5-substituted 4-acyloxazoles and the related 2,4-substituted 5-acyloxazoles with complementar...
期刊名称:《Synthesis: International Journal of Methods in Synthetic Organic Chemistry》 | 2016年第2期 关键词: silver; ring opening; alkynylation; cyclopropanol; alkyne; 3.Palladium-Catalyzed Cross-Coupling of 4-Tosyloxyquinazolines with Organoindium Reagents: An Efficient Route to 4-Substituted Qui...
ChemInform Abstract: Highly Functionalized 3,4,5-Trisubstituted 1,2,4-Triazoles for Future Use as Ligands in Coordination Polymers. ChemInform is a weekly ing Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform ... Daniel,...
Oxazoles are a kind of attractive heterocycles not only because of their unique structures and varied applications [1, 2] but also they serve as structural elements for a variety of natural products, pharmaceuticals and bioactive compounds [3–5]. For example, the diazonamide and phorboxazole fa...
Copper-Catalyzed Three-Component Domino Cyclization for the Synthesis of 4-Aryl-5-(arythio)-2-(trifluoromethyl)oxazoles A copper-catalyzedoxidative cyclization of oxime, arylthiol, andtrifluoroacetic anhydride for the construction of trisubstituted oxazoleshas been developed. This transformation combines N...
multicomponent reactionsThe first Au(I)-catalyzed synthesis of highly substituted oxazole derivatives via one-pot, multicomponent reaction of amides, alkynes, and aldehydes is developed.Pierre QuerardDep. Chem.Simon A. GirardDep. Chem.Nick Uhlig...
Forsyth, who was the first to complete the synthesis of either natural product (Figure 2),11 established the Michael cyclization to the pentasubstituted pyran and developed a biomimetic route to the oxazoles. He observed the same lack of diastereoselectivity in the formation of the C38 center ...