The synthesis of 1-(phenylsulfonyl)pyrrole-2-boronic acid has been accomplished by a process involving the directed lithiation of 1-(phenylsulfonyl)-pyrrole. The former has been shown to couple smoothly with aryl bromides and iodides under Suzuki conditions to afford 2-aryl-1-(phenylsulfonyl)...
The synthesis of 1-(phenylsulfonyl)pyrrole-2-boronic acid has been accomplished by a process involving the directed lithiation of 1-(phenylsulfonyl)-pyrrol... JG Grieb,DM Ketcha - 《Synthetic Communications》 被引量: 38发表: 1995年 Synthesis of benzo[d]-1,2-thiazole-1,1-dioxide derivatives...
One by one or two by two: In a general approach to the iterative construction of oligopyrroles, the cycloaddition of azomethine ylides derived from pyrrolyl -iminoesters with 1,2-bis(phenylsulfonyl)ethylene is followed by the elimination of the sulfonyl groups in situ under basic conditions. ...
Intramolecular cyclization of 1-(2-aminophenylsulfonyl)-1H-pyrrole-2-acetic acid 5 gave 10H-pyirolo[1,2-b][1,2,6]benzothiadiazocin-11(12H)-one 5,5-dioxide 4, a novel heterocyclic system of pyrrolobenzothiadiazocine family. Compound 5 was obtained starting from 2-nitrobenzenesulfonyl chlorid...
Strychnine is a heptacyclic indole alkaloid that belongs to the Strychnosfamily (Fig. 1). First to be isolated and despite its toxicity, synthesis of thisc... H Zhang,J Boonsombat,A Padwa - 《Chemtracts》 被引量: 0发表: 2008年 Total synthesis of (±)-N2-(phenylsulfonyl)-CPI, (...
1 2-Chloro-1(2-alkylamino)phenyl)ethan-1-one derived from arylamine underwent cyclization through intramolecular displacement reaction in the presence of NaH in dimethoxyethane (DME) at 0°C delivered N-substituted indolin-3-one. 2 N-Phenylsulfonyl-1,2-dihydro-3H-indol-3-one has been synthesiz...
Another IIae pyrrole cyclization involves nucleophilic addition of amines to electrophilic 1,3-dienes. The reaction pattern has been realized with 2,3-diphenylsulfonyl-1,3-butadiene and with 2-acetyl-3-phenylsulfonyl-1,3-butadiene 〈88TL3041, 91S171〉. Elimination of phenylsulfinate, induced by...
This study describes an improved one-pot, four-step synthesis of a new series of 1-aryl-3-trifluoroacetyl pyrroles from the reaction of 3-trifluoroacetyl-4,5-dihydrofuran with arylamines, giving 1,1,1-trifluoro-3-(2-hydroxyethyl)-4-arylamino-3-buten-2- ones, which were directly submitte...
Cyclization of vicinal alkyl acylamines (139) induced by strong bases [the Madelung reaction and its modifications (68AHC27)] is a versatile method for preparing fused pyrroles (140); in the general representation in Scheme 31 the intermediate is depicted as a carbanion for simplicity, although...
In this review, we summarize recent advances (mainly from 2010 to 2023) in the synthesis of N-heterocycles, such as pyrroles, indoles, pyridines, and benzodiazepines, catalyzed by heteropolyacids (HPAs), modified HPA catalysts, and transition metal-modified POMs. The prospects of POM-based ...