Ribonucleic acid synthesis was studied at different times in the life cycle of a synchronized population of L5178Y mouse leukemic cells. The rate of RNA synthesis, indicated by the specific activity of the isolated RNA after a pulse label with 3 H-5- uridine, approximately doubled as cells mov...
Thus, in subsequent autoradiographs, only cells which had been synthesizing DNA during exposure to the precursor were labelled. The ages of these individuals within the cell cycle were estimated by measuring their sizes. This revealed that incorporation into DNA occurred almost exclusively during the ...
Brief Total Synthesis of the Cell Cycle Inhibitor Tryprostatin B (I) and Related Preparation of Its Alanine Analogue (II). E, Avendano C, Menendez JC (2003) Brief total synthesis of the cell cycle inhibitor tryprostatin B and related preparation of its alanine analogue. J... E Caballero,...
The role of prostaglandin 12 (PGI 2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G 0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [...
AIM To investigate cell cycle and DNA synthesisduring myocytic differentiation. METHODS Murine C2C12 myoblasts were used in this experiment. The control group was cultured in Dulbeccco's modified eagle's medium (DMEM) supplemented with 100 mL·L -1 fetal bovine serum (FBS). Proliferating myoblas...
Accumulation of nucleotide building blocks prior to and during S phase facilitates DNA duplication. Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels and DNA synthesis during the cell cycle. In late G1and S phases, transketolase-like 1 ...
Cyclin synthesis drives the early embryonic cell cycle. We have produced extracts of frog eggs that can perform multiple cell cycles in vitro. Destruction of the endogenous messenger RNA arrests the extracts in ... A W,Murray,M W,... - 《Nature》 被引量: 2305发表: 1989年 Punc...
may influence the translation process. PD-associated genetic mutations in mitochondrial proteins are indicated by lightning bolts. Post-translational modification enzymes represent the numerous alterations made to polypeptides and proteins during their lifetime in the cell, which may be deregulated in PD....
Cell Cycle: Control of Entry and Progression Through S Phase Susan L.Forsburg, inEncyclopedia of Biological Chemistry, 2004 Origins DNA synthesisbegins at replication origins. Generally, there are many replication origins in each chromosome, to facilitate the timely duplication of the genome. In a ...
et al. Autophosphorylation of the bacterial tyrosine-kinase CpsD connects capsule synthesis with the cell cycle in Streptococcus pneumoniae. PLos Genet. 11, e1005518 (2015). Article PubMed PubMed Central Google Scholar Hall, C. L. et al. Structure and dimerization of IreB, a negative ...