SynergyFinder 允许按浓度加权协同作用,因此突出显示在较低剂量窗口显示协同作用的组合,因为这些组合不太可能导致毒性反应。由于药物浓度范围在联合检测中通常是异质的,SynergyFinder 不直接使用药物剂量,而是使用每个剂量下单一药物的响应值比例。通过这种方式,SynergyFinder 隐含地支持较低浓度的协同作用,而无需利用真实的药...
SynergyFinder 允许按浓度加权协同作用,因此突出显示在较低剂量窗口显示协同作用的组合,因为这些组合不太可能导致毒性反应。由于药物浓度范围在联合检测中通常是异质的,SynergyFinder 不直接使用药物剂量,而是使用每个剂量下单一药物的响应值比例。通过这种方式,SynergyFinder 隐含地支持较低浓度的协同作用,而无需利用真实的药...
SynergyFinder利用了多种数学模型和算法来预测和评估药物组合的协同效应。 组合索引 SynergyFinder使用组合索引来评估药物组合的效应。组合索引基于剂量-效应曲线,通过计算不同药物组合的组合效应指数来量化其协同效应。组合效应指数表达了组合药物与单药疗效之间的差异。 Loewe模型 SynergyFinder基于Loewe模型进行组合效应的计算...
50, Web Server issue W739–W743https://doi.org/10.1093/nar/gkac382SynergyFinder 3.0: an interactive analysis andconsensus interpretation of multi-drug synergiesacross multiple samplesAleksandr Ianevski 1,2,* , Anil K. Giri 1,3,* and Tero Aittokallio1,2,4,5,*1 Institute for Molecular ...
As the SynergyFinder R package provides four synergy models (i.e., HSA, BLISS, LOEWE, and ZIP) that differ in their null hypotheses of non-interaction, the synergy scores do not necessarily coincide with each other for a given dataset. To provide a more harmonized representation of the syne...
SynergyFinder: a web application for analyzing drug combination dose-response matrix data. Bioinformatics. 2017;33(15):2413-5.Ianevski A, He L, Aittokallio T, Tang J. SynergyFinder: a web application for analyzing drug combination dose- response matrix data. Bioinformatics. 2017; 33:2413-15....
add synergyfinder Sep 27, 2016 .travis.yml only keep bioconductor in .travis.yml Jan 29, 2018 DESCRIPTION fixes for missing concentration units merging from branch RELEASE_3_6 Feb 6, 2018 LICENSE change license to Mozilla Public License 2.0 ...
SynergyFinder2.0:visualanalyticsofmulti-drug combinationsynergies AleksandrIanevski 1,2,* ,AnilK.Giri 1,* andTeroAittokallio 1,2,3,4,* 1 InstituteforMolecularMedicineFinland(FIMM),HiLIFE,UniversityofHelsinki,FI-00290Helsinki,Finland, 2 Helsinki InstituteforInformationTechnology(HIIT),DepartmentofComputer...
SynergyFinder: a web application for analyzing drug combination dose-response matrix data (vol 33, pg 2431, 2017) Ianevski A, He L, Aittokallio T, Tang J. SynergyFinder: a web application for analyzing drug combination dose-response matrix data. Bioinformatics 2017;... A Ianevski,L He,T ...
SynergyFinder (https://synergyfinder.fimm.fi) 是一个独立的网络应用程序,用于药物组合筛选数据的交互式分析和可视化。自 2017 年首次发布以来,SynergyFinder 已成为广泛使用的网络工具,用于在临床前模型系统(例如细胞系或原代患者来源的细胞)中发现新型协同药物组合,以及更好地了解协同药物组合的机制联合治疗的疗效或...