SynergyFinder 允许按浓度加权协同作用,因此突出显示在较低剂量窗口显示协同作用的组合,因为这些组合不太可能导致毒性反应。由于药物浓度范围在联合检测中通常是异质的,SynergyFinder 不直接使用药物剂量,而是使用每个剂量下单一药物的响应值比例。通过这种方式,SynergyFinder 隐含地支持较低浓度的协同作用,而无需利用真实的药...
SynergyFinder利用了多种数学模型和算法来预测和评估药物组合的协同效应。 组合索引 SynergyFinder使用组合索引来评估药物组合的效应。组合索引基于剂量-效应曲线,通过计算不同药物组合的组合效应指数来量化其协同效应。组合效应指数表达了组合药物与单药疗效之间的差异。 Loewe模型 SynergyFinder基于Loewe模型进行组合效应的计算...
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synergyfinder: Calculate and Visualize Synergy Scores for Drug CombinationsLiye HeJing Tang
50, Web Server issue W739–W743https://doi.org/10.1093/nar/gkac382SynergyFinder 3.0: an interactive analysis andconsensus interpretation of multi-drug synergiesacross multiple samplesAleksandr Ianevski 1,2,* , Anil K. Giri 1,3,* and Tero Aittokallio1,2,4,5,*1 Institute for Molecular ...
As the SynergyFinder R package provides four synergy models (i.e., HSA, BLISS, LOEWE, and ZIP) that differ in their null hypotheses of non-interaction, the synergy scores do not necessarily coincide with each other for a given dataset. To provide a more harmonized representation of the syne...
SynergyFinder (https://synergyfinder.fimm.fi) 是一个独立的网络应用程序,用于药物组合筛选数据的交互式分析和可视化。自 2017 年首次发布以来,SynergyFinder 已成为广泛使用的网络工具,用于在临床前模型系统(例如细胞系或原代患者来源的细胞)中发现新型协同药物组合,以及更好地了解协同药物组合的机制联合治疗的疗效或...
SynergyFinder2.0:visualanalyticsofmulti-drug combinationsynergies AleksandrIanevski 1,2,* ,AnilK.Giri 1,* andTeroAittokallio 1,2,3,4,* 1 InstituteforMolecularMedicineFinland(FIMM),HiLIFE,UniversityofHelsinki,FI-00290Helsinki,Finland, 2 Helsinki InstituteforInformationTechnology(HIIT),DepartmentofComputer...
add synergyfinder Sep 27, 2016 .travis.yml only keep bioconductor in .travis.yml Jan 29, 2018 DESCRIPTION fixes for missing concentration units merging from branch RELEASE_3_6 Feb 6, 2018 LICENSE change license to Mozilla Public License 2.0 ...
The outcome panels of the SynergyFinder web application. (a) Visualization of the dose–response matrix and the plots of phenotypic responses for the single drugs. (b) Visualization of the calculated 2D and 3D synergy maps Open in new tabDownload slide2.2...